4432-97-7Relevant academic research and scientific papers
A catalyst for asymmetric induction
-
, (2008/06/13)
A catalyst for asymmetric induction is provided which comprises a titanium (IV) alkoxide and an amino acid amide derivative of formula (I): wherein R1 is isopropyl, isobutyl, sec-butyl, tert-butyl, phenyl or benzyl, R2 and R3 are the same or different and each is lower alkyl, C3 to C8 cycloalkyl, unsubstituted or substituted phenyl or hydrogen or R2 and R3 together form a divalent C3 to C7 alkylene group optionally containing one or more hetero atoms, R4 is chlorine, bromine, iodine, lower alkyl or unsubstituted or substituted phenyl, R5, R6 and R7 are the same or different and each is hydrogen, halogen, methyl or methoxy or R5 is as defined above and R6 and R7 together form -CH=CH-CH=CH- or -OCH2O- or R7 is as defined above and R5 and R6 together form -CH=CH-CH=CH- or -OCH2O- and * denotes an absolute configuration of S or R.
