443770-62-5Relevant academic research and scientific papers
Collective synthesis of 4-hydroxy-2-pyridone alkaloids and their antiproliferation activities
Ding, Feiqing,Leow, Min Li,Ma, Jimei,William, Ronny,Liao, Hongze,Liu, Xue-Wei
supporting information, p. 2548 - 2554 (2014/10/15)
A collective synthesis of 4-hydroxy-2-pyridone alkaloids - specifically, pretenellin B, prebassianin B, farinosone A, militarione D, pyridovericin, and torrubiellone C - has been achieved. Key steps include using a strategic convergent method to synthesize the densely substituted pyridone key intermediate by Suzuki-Miyaura cross-coupling reaction, a divergent synthesis approach of target molecules by aldol condensation of pyridone intermediate with homologous aldehydes, and an iterative synthesis of homologous aldehydes with all-trans-polyene backbones. Interestingly, among the six tumor cell lines investigated, torrubiellone C was found to induce potent and apoptotic inhibitory activities on Jurkat T cells with IC50 values of 7.05 μM. Hence, this approach could potentially contribute to the synthesis of bioactive small-molecule libraries as well as drug discovery.
Total synthesis of pyridovericin
Irlapati, Nageswara Rao,Adlington, Robert M.,Conte, Aurelia,Pritchard, Gareth J.,Marquez, Rodolfo,Baldwin, Jack E.
, p. 9307 - 9317 (2007/10/03)
The total synthesis of the naturally occurring kinase inhibitor pyridovericin 1 is reported. A flexible and efficient synthesis has been accomplished in good yield from readily available 2,4-dihydroxypyridine. Pyridovericin is a key intermediate in our pr
Total synthesis of pyridovericin: studies toward the biomimetic synthesis of pyridomacrolidin.
Baldwin, Jack E,Adlington, Robert M,Conte, Aurelia,Irlapati, Nageswara Rao,Marquez, Rodolfo,Pritchard, Gareth J
, p. 2125 - 2127 (2007/10/03)
[reaction: see text] The total synthesis of the novel metabolite pyridovericin 1 is reported. The synthesis of this key intermediate in our proposed biomimetic synthesis of pyridomacrolidin 2 has been accomplished in good yield from readily available 2,4-dihydroxypyridine.
