443777-09-1Relevant articles and documents
Total Synthesis of Pactalactam, an Imidazolidinone-Type Pactamycin Analogue
Kim, Taejung,Matsushita, Shohei,Matsudaira, So,Doi, Tsuyoshi,Hirota, Shinji,Park, Young-Tae,Igarashi, Masayuki,Hatano, Masaki,Ikeda, Noriko,Ham, Jungyeob,Nakata, Masaya,Saikawa, Yoko
, p. 3554 - 3557 (2019)
The first total synthesis of pactalactam was accomplished using substrate-controlled stereoselective aziridination and regioselective aziridine ring-opening to construct three continuous amino groups on an octasubstituted cyclopentane core. The cyclopentane framework was obtained by ring-closing metathesis and aldol coupling using a l-threonine-derived oxazoline compound. Cyclic urea formation, m-acetylphenyl group introduction by Chan-Lam coupling, and primary alcohol-selective acylation yielded the reported pactalactam structure. The presence of pactalactam in the fermentation broth of pactamycin-producing bacteria was also confirmed.
Heterogeneous Pd/C-catalyzed ligand-free Suzuki-Miyaura coupling reaction using aryl boronic esters
Kitamura, Yoshiaki,Sakurai, Ai,Udzu, Takahiro,Maegawa, Tomohiro,Monguchi, Yasunari,Sajiki, Hironao
, p. 10596 - 10602 (2008/02/12)
Heterogeneous Pd/C-catalyzed Suzuki-Miyaura cross-coupling reaction of aryl boronic esters with aryl bromides was successfully carried out in aqueous media at room temperature without the use of a ligand such as phosphine derivatives.
