443920-01-2

Basic information

• Product Name: methanesulfonic acid 1-(4-methanesulfonyl-phenyl)-5-phenyl-1H-pyrazol-3-ylmethyl ester
• Synonyms: methanesulfonic acid 1-(4-methanesulfonyl-phenyl)-5-phenyl-1H-pyrazol-3-ylmethyl ester
• CAS NO: 443920-01-2
• Molecular Weight: 406.483
• Mol File: 443920-01-2.mol

Chemical Properties

• CAS DataBase Reference: methanesulfonic acid 1-(4-methanesulfonyl-phenyl)-5-phenyl-1H-pyrazol-3-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: methanesulfonic acid 1-(4-methanesulfonyl-phenyl)-5-phenyl-1H-pyrazol-3-ylmethyl ester(443920-01-2)
• EPA Substance Registry System: methanesulfonic acid 1-(4-methanesulfonyl-phenyl)-5-phenyl-1H-pyrazol-3-ylmethyl ester(443920-01-2)

Safety Data

• Hazardous Substances Data: 443920-01-2(Hazardous Substances Data)

Upstream product

• 17852-67-4 4-(methylsulfonyl)phenylhydrazine hydrochloride 
• 443919-99-1 1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester 
• 98-86-2 acetophenone 
• 6296-54-4 ethyl 2,4-dioxo-4-phenylbutyrate 
• 124-63-0 methanesulfonyl chloride 
• 443920-00-1 3-hydroxymethyl-1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazole 

Downstream Products

• 1287760-89-7 1-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-ylmethyl]-3-(3-trifluoromethylphenyl)-urea 
• 1287760-88-6 1-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-ylmethyl]-3-(4-trifluoromethylphenyl)-urea 
• 1287760-87-5 1-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-ylmethyl]-3-(4-trifluoromethoxyphenyl)-urea 
• 1287760-86-4 1-[1-(4-methanesulfonyl-phenyl)-5-phenyl-1H-pyrazol-3-ylmethyl]-3-phenyl-urea 
• 1287760-85-3 1-cycloheptyl-3-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-ylmethyl]-urea 
• 1287760-84-2 1-adamantan-1-yl-3-[1-(4-methanesulfonyl-phenyl)-5-phenyl-1H-pyrazol-3-ylmethyl]-urea 
• 1287761-05-0 C-[1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazol-3-yl]methylamine 
• 1287761-03-8 3-azidomethyl-1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazole 

Relevant articles and documents

Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor

Dual COX-2/5-LO inhibitors are described as potential new therapeutic agents for inflammatory diseases. A surprisingly potent effect of a 5-LO pharmacophoric group on the COX-2 inhibition is presented as well as pharmacological in vitro and in vivo results.

Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase

A series of dual inhibitors containing a 1,5-diarylpyrazole and a urea were designed, synthesized, and evaluated as novel COX-2/sEH dual inhibitors in vitro using recombinant enzyme assays and in vivo using a lipopolysaccharide (LPS) induced model of pain in rats. The best inhibition potencies and selectivity for sEH and COX-2 over COX-1 were obtained with compounds (21b, 21i, and 21j) in which both the 1,5-diaryl-pyrazole group and the urea group are linked with a three-methylene group. Compound 21i showed the best pharmacokinetic profiles in both mice and rats (higher AUC and longer half-life). Following subcutaneous administration at 10 mg/kg, compound 21i exhibited antiallodynic activity that is more effective than the same dose of either a COX-2 inhibitor (celecoxib) or a sEH inhibitor (t-AUCB) alone, as well as coadministration of both inhibitors. Thus, these novel dual inhibitors exhibited enhanced in vivo antiallodynic activity in a nociceptive behavioral assay.