443955-98-4

Usage

Uses

Used in Pharmaceutical Synthesis:
trans-4-Amino-1-Boc-3-hydroxypiperidine is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its presence allows for the creation of complex molecular structures with potential therapeutic applications, making it an essential component in drug discovery and development processes.
Used in Organic Synthesis:
In the realm of organic synthesis, trans-4-Amino-1-Boc-3-hydroxypiperidine serves as a valuable building block. Its unique structure and functional groups enable the formation of a wide range of organic compounds, facilitating the exploration of new chemical entities and expanding the scope of chemical research.
Used in Drug Discovery:
trans-4-AMino-1-Boc-3-hyd... is employed in drug discovery processes within the pharmaceutical industry. Its versatile reactivity and functional group tolerance make it a preferred choice for the development of new chemical entities, potentially leading to the creation of innovative and effective medications.

Upstream product

• 161157-50-2 tert-butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 694-05-3 1,2,3,6-tetrahydropyridine 
• 85838-94-4 N-Boc-1,2,3,6-tetrahydropyridine 
• 203503-02-0 tert-butyl (3RS,4RS)-4-azido-3-hydroxy-piperidine-1-carboxylate 
• 71233-25-5 ethyl 1-tert-butoxycarbonyl-3-oxopiperidine-4-carboxylate 
• 71233-28-8 3-hydroxypiperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester 
• 1427170-50-0 C₁₁H₂₀N₂O₄ 
• 13139-12-3 tert-butyl 2,5-dioxopyrrolidin-1-yl carbonate 
• 1007596-94-2 (3R,4R)-4-aminopiperidin-3-ol 
• 1161931-95-8 (3R,4R)-4-benzylamino-3-hydroxy-4-piperidine-1-carboxylic acid tert-butyl ester 
• 959617-87-9 benzyl (3R,4R)-4-amino-3-hydroxy-piperidine-1-carboxylate 
• 167832-25-9 trans(±)benzyl-4-azido-3-hydroxypiperidine-1-carboxylate 
• 66207-08-7 3,4-epoxy-piperidine-1-carboxylic acid benzyl ester 

Downstream Products

• 1565853-00-0 C₁₆H₃₀N₂O₃ 
• 1565846-67-4 C₁₈H₂₆BrN₃O₃ 
• 1007596-96-4 (3R,4R)-tert-butyl 3-azido-4-[(diphenylmethylene)amino]piperidine-1-carboxylate 

Relevant academic research and scientific papers

TBK/IKK INHIBITOR COMPOUNDS AND USES THEREOF

The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKKε inhibitors.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula (I) (Formula (I)) including pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

PYRROLO[2,3-D]PYRIMIDINYL, PYRROLO[2,3-B]PYRAZINYL AND PYR-ROLO[2,3-D]PYRIDINYL ACRYLAMIDES

The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl and pyrrolo[2,3-d]pyridinyl acrylamides and analogues thereof. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.

Synthesis and in vitro antibacterial activity of quinolone/naphthyridone derivatives containing 3-alkoxyimino-4-(methyl)aminopiperidine scaffolds

We report herein the synthesis of a series of 7-[3-alkoxyimino-4-(methyl) aminopiperidin-1-yl]quinolone/naphthyridone derivatives. In vitro antibacterial activity of these derivatives was evaluated against representative strains, and compared with ciprofl

METHYLPYRROLOPYRIMIDINECARBOXAMIDES

The compounds of Formula (I), wherein R1, R2, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, the stereoisomers of the compounds and the salts thereof are effective inhibitors of the type 5 phosphodiesterase.

METHYLPYRROLOPYRIMIDINECARBOXAMIDES

The compounds of formula (I) wherein R1, R2, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, and the stereoisomers of the compounds and the salts thereof are effective inhibitors of the type 5 phosphodiestera

METHYLPYRROLOPYRIDINECARBOXAMIDES

The compounds of formula (I) wherein R1, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, and the stereoisomers of the compounds and the salts thereof are effective inhibitors of the type 5 phosphodiesterase.

PIPERIDINYL SUBSTITUTED 1,3-DIHYDRO-BENZOIMIDAZOL-2-YLIDENEAMINE DERIVATIVES

The invention relates to new derivatives of formula (I) wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of one or more IGF-1R mediated disorders or diseases

IMIDAZOLE CARBONYL COMPOUND

To develop an antibiotic having a novel mechanism of action, the present inventors have searched for a compound that has weak cytotoxicity, the physical property of high solubility in water, the effect of inhibiting both DNA gyrase GyrB and topoisomerase IV ParE subunits, and sufficient antibacterial activity. As a result, the present inventors have completed the present invention by finding that a compound of the present invention represented by the general formula (1), a pharmacologically acceptable salt thereof, and a prodrug thereof have desirable properties. The present invention provides a pharmaceutical composition (particularly, a preventive or therapeutic composition for infectious disease) comprising a compound represented by the formula (1), a pharmacologically acceptable salt thereof, or a prodrug thereof as an active ingredient.

PIPERIDINYL CYCLIC AMIDO ANTIVIRAL AGENTS

Provided are compounds of Formula (I) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV).