4441-34-3

Basic information

• Product Name: r-[2-(4-morpholinyl)ethyl]-
• CAS NO: 4441-34-3
• Molecular Weight: 221.299
• Mol File: 4441-34-3.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: r-[2-(4-morpholinyl)ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: r-[2-(4-morpholinyl)ethyl]-(4441-34-3)
• EPA Substance Registry System: r-[2-(4-morpholinyl)ethyl]-(4441-34-3)

Safety Data

• Hazardous Substances Data: 4441-34-3(Hazardous Substances Data)

Upstream product

• 2298-48-8 3-morpholin-4-yl-1-phenyl-propan-1-one 
• 98-86-2 acetophenone 
• 110-91-8 morpholine 
• 4393-06-0 1-Phenyl-2-propen-1-ol 
• 18776-12-0 3-chloro-1-phenyl-propan-1-ol 
• 936-59-4 3-chloropropiophenone 
• 93-54-9 1-Phenyl-1-propanol 
• 25039-19-4 (E)-3-morpholino-1-phenyl-2-propen-1-one 
• 62872-58-6 3-iodo-1-phenyl-propan-1-ol 
• 4436-23-1 2-phenyloxetane 
• 1020-16-2 3-morpholino-1-phenylpropan-1-one hydrochloride 

Downstream Products

• 157846-66-7 Methanesulfonic acid 3-morpholin-4-yl-1-phenyl-propyl ester 
• 1384515-34-7 2-phenylhexahydro-2H-[1,3]oxazino[2,3-c][1,4]oxazine 
• 157846-75-8 4-[3-(3,4-Dimethoxy-phenoxy)-3-phenyl-propyl]-morpholine 
• 157846-72-5 4-[3-(2-Methoxy-phenoxy)-3-phenyl-propyl]-morpholine 
• 157846-73-6 4-[3-(3-Methoxy-phenoxy)-3-phenyl-propyl]-morpholine 
• 157846-74-7 4-[3-(4-Methoxy-phenoxy)-3-phenyl-propyl]-morpholine 
• 157846-71-4 4-(3-phenoxy-3-phenyl-propyl)-morpholine 
• 26409-35-8 3-(4-oxy-morpholin-4-yl)-1-phenyl-propan-1-ol 
• 173366-49-9 1-chloro-3-morpholino-1-phenylpropane 
• 25901-61-5 4-(3-hydroxy-3-phenyl-propyl)-morpholin-3-one 
• 14611-98-4 N-(3-morpholin-4-yl-1-phenyl-propyl)-acetamide 

Relevant articles and documents

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Iron-Catalyzed Anti-Markovnikov Hydroamination and Hydroamidation of Allylic Alcohols

Hydroamination allows for the direct access to synthetically important amines. Controlling the selectivity of the reaction with efficient, widely applicable, and economic catalysts remains challenging, however. This paper reports an iron-catalyzed formal anti-Markovnikov hydroamination and hydroamidation of allylic alcohols, which yields γ-amino and γ-amido alcohols, respectively. Homoallylic alcohol is also feasible. The catalytic system, consisting of a pincer Fe-PNP complex (1-4 mol %), a weak base, and a nonpolar solvent, features exclusive anti-Markovnikov selectivity, broad substrate scope (>70 examples), and good functional group tolerance. The reaction could be performed at gram scale and applied to the synthesis of drug molecules and heterocyclic compounds. When chiral substrates are used, the stereochemistry and enantiomeric excess are retained. Further application of the chemistry is seen in the functionalization of amino acids, natural products, and existing drugs. Mechanistic studies suggest that the reaction proceeds via two cooperating catalytic cycles, with the iron complex catalyzing a dehydrogenation/hydrogenation process while the amine substrate acts as an organocatalyst for the Michael addition step.

Synthesis and antimicrobial activity of some new 1,2,4-triazine and benzimidazole derivatives

1-(4-Substituted phenyl)-3-(substituted)propan-1-(1H-benzo[d]imidazol-2-yl) hydrazines and 1-(4-substituted phenyl)- 3-(substituted)propan-1-(5H-[1,2,4] triazino[5,6-b]indol-3-yl) hydrazines have been synthesized by the fusion of triazine and benzimidazole derivatives with Mannich bases. The synthesized compounds have been characterized and screened against ITCC 5226 Sclerotium rolfsii and ITCC 0482 Macrophomina phaseolina and MTCC739 Escherichia coli, ATCC6533 Bacillus subtilis, ATCC9144 Staphylococcus aureus, ATCC25619 Pseudomonas aeruginosa and ATCC24433 Candida albicans.