25039-19-4

Upstream product

• 98-86-2 acetophenone 
• 35534-35-1 morpholino-diethoxy-methane 
• 110-91-8 morpholine 
• 2298-48-8 3-morpholin-4-yl-1-phenyl-propan-1-one 
• 5337-93-9 4'-methylpropiophenone 
• 93-55-0 1-phenyl-propan-1-one 
• 2579-22-8 Phenylpropargyl aldehyde 
• 1504-58-1 3-Phenyl-2-propyn-1-ol 
• 3623-15-2 phenyl propargyl ketone 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 93-54-9 1-Phenyl-1-propanol 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 122438-01-1 (2-Morpholin-4-yl-2H-chromen-3-yl)-phenyl-methanone 
• 122438-07-7 (8-Methoxy-2-morpholin-4-yl-2H-chromen-3-yl)-phenyl-methanone 
• 2298-48-8 3-morpholin-4-yl-1-phenyl-propan-1-one 
• 4441-34-3 3-morpholino-1-phenylpropan-1-ol 
• 56570-47-9 (Z)-3-(benzylamino)-1-phenylprop-2-en-1-one 
• 34597-73-4 3-(Benzylamino)-1-phenyl-1-propanol 
• 122438-04-4 (6-Bromo-2-morpholin-4-yl-2H-chromen-3-yl)-phenyl-methanone 
• 122438-10-2 (3-Morpholin-4-yl-3H-benzo[f]chromen-2-yl)-phenyl-methanone 
• 122438-03-3 (6-Chloro-2-morpholin-4-yl-2H-chromen-3-yl)-phenyl-methanone 
• 122438-06-6 (2-Morpholin-4-yl-6-nitro-2H-chromen-3-yl)-phenyl-methanone 
• 122438-08-8 (6-Bromo-8-methoxy-2-morpholin-4-yl-2H-chromen-3-yl)-phenyl-methanone 
• 122438-05-5 (6-Fluoro-2-morpholin-4-yl-2H-chromen-3-yl)-phenyl-methanone 
• 120450-91-1 3-benzoyl-4H-chromene 
• 122438-09-9 (6,8-Dibromo-2-morpholin-4-yl-2H-chromen-3-yl)-phenyl-methanone 

Relevant academic research and scientific papers

Fe-Catalyzed enaminone synthesis from ketones and amines

We have developed an iron-catalyzed direct olefination for enaminone synthesis, with saturated ketones as a source of olefins. This direct ketone β-functionalization reaction has readily available starting materials and a wide range of substrates and requires mild reaction conditions.

Compounds containing N-alpha, beta unsaturated ketone and preparation method and application of compounds

The invention belongs to the technical field of organic synthesis and particularly relates to compounds containing N-alpha, beta unsaturated ketone and a preparation method and application of the compounds. The preparation method includes: dissolving a co

Intermolecular Multiple Dehydrogenative Cross-Couplings of Ketones with Boronic Acids and Amines via Copper Catalysis

An efficient and versatile oxidative coupling reaction was developed for the synthesis of valuable β-functionalized unsaturated ketones and meta-substituted phenols. In the case of intramolecular reactions, achieving rapid molecular complexity through multiple dehydrogenative couplings is already a well-established strategy. Herein, we report an intermolecular multiple dehydrogenative coupling between ketones and nucleophilic amines or boronic acids using inexpensive copper(I) oxide as a catalyst. This method provides a facile access to highly desirable chemical products such as α,β-unsaturated ketones, enaminones, and synthetically relevant meta-substituted phenols. (Figure presented.).

Highly Site-Selective Metal-Free C-H Acyloxylation of Stable Enamines

A highly site-selective acyloxylation of stable enamines with PhI(OAc)2 under metal-free conditions to afford (E)-vinyl acetate derivatives in good to excellent yields is described. Depending on the judicious choice of the solvent system, either the α- or β-site-selective product could be obtained with high selectivity. For the α-site-selective product, the rearranged amide compound is obtained as the major product. This reaction proceeds under mild reaction conditions (room temperature, metal-free, and open-flask) and features a broad substrate scope.

Synthesis of Polyaromatic Rings: Rh(III)-Catalyzed [5 + 1] Annulation of Enaminones with Vinyl Esters through C-H Bond Functionalization

An expedient [5 + 1] annulation method via Rh(III)-catalyzed C-H bond functionalization of enaminones to synthesize polyaromatic rings is described. The reaction tolerates a broad range of functional groups and offers a new entry to construct polycyclic a

Synthesis of Polyaromatic Rings: Rh(III)-Catalyzed [5 + 1] Annulation of Enaminones with Vinyl Esters through C-H Bond Functionalization

An expedient [5 + 1] annulation method via Rh(III)-catalyzed C-H bond functionalization of enaminones to synthesize polyaromatic rings is described. The reaction tolerates a broad range of functional groups and offers a new entry to construct polycyclic a

Silver-catalyzed efficient synthesis of enaminones from propargyl alcohols and amines

Enaminones are used as the key intermediates to construct heterocyclic compounds with various bioactivities. In this study, a simple and efficient approach for the synthesis of enaminones via amination of propargyl alcohols was developed. Under the catalysis of Ag2CO3, the reaction proceeded smoothly to afford the desired products in good yields. Preliminary mechanism experiments showed that Ag2CO3 played an essential role in the procedure of the reaction.

Tunable and Diastereoselective Br?nsted Acid Catalyzed Synthesis of β-Enaminones

The Br?nsted acid catalyzed Meyer-Schuster reaction of hemiaminals was studied for the stereoselective synthesis of β-enaminones. Hemiaminals were formed from propargyl aldehydes (or the oxidation of propargyl alcohols) and amines in the presence of Br?ns

Transformation of α-substituted propanols into γ-amino alcohols through nickel-catalyzed amination on the terminal γ-carbon of propanols

A nickel-phosphine complex was found to be effective as the catalyst for the transformation of alcohols into β-enaminones, which was successively converted into γ-amino alcohols by a conventional reductant. The sequential transformation is equivalent to the carbon-nitrogen bond formation at the γ-position of saturated alcohols. Georg Thieme Verlag Stuttgart · New York.