444995-68-0Relevant academic research and scientific papers
Transition-metal-free synthesis of benzimidazoles mediated by KOH/DMSO
Baars, Hannah,Beyer, Astrid,Kohlhepp, Stefanie V.,Bolm, Carsten
supporting information, p. 536 - 539 (2014/04/03)
Benzimidazoles are prepared by intramolecular N-arylations of amidines mediated by potassium hydroxide in DMSO at 120 °C. In this manner, diversely substituted products have been obtained in moderate to very good yields.
Synthesis of annulated benzimidazoles via amidine cyclization
Liubchak, Kostiantyn,Nazarenko, Kostiantyn,Tolmachev, Andrey
experimental part, p. 2993 - 3000 (2012/05/31)
Structurally diverse annulated benzimidazoles were synthesized via two copper(I)-catalyzed cyclocondensation reactions. In the first case the title compounds were prepared from lactams and o-bromoaniline. An alternative route consisted of an intramolecular cyclization of o-bromoarylamidines.
An intramolecular palladium-catalysed aryl amination reaction to produce benzimidazoles
Brain, Christopher T,Brunton, Shirley A
, p. 1893 - 1895 (2007/10/03)
A novel synthesis of benzimidazoles by a palladium-catalysed intramolecular N-arylation reaction from (o-bromophenyl)amidine precursors is described.
