445306-73-0Relevant articles and documents
Stereoselective synthesis of C3-C12 dihydropyran portion of antitumor laulimalide using copper-catalyzed oxonium ylide formation-[2,3] shift
Yakura, Takayuki,Muramatsu, Wataru,Uenishi, Jun'ichi
, p. 989 - 994 (2007/10/03)
Copper-catalyzed oxonium ylide formation-[2,3] shift of (5S,7R)-5-allyloxy-1-diazo-8-(p-methoxybenzyloxy)-7-methyl-2-octanone (3) proceeded in tetrahydrofuran-dichloromethane (4 : 1) under reflux with an excellent stereoselectivity (97 : 3) to give (2R,6S
Total synthesis of the antitumor agent (-)-laulimalide
Mulzer, Johann,Hanbauer, Martin
, p. 3381 - 3383 (2007/10/03)
A stereocontrolled synthesis of the title compound is described. Key steps are an allylsilane addition to a chiral acetal as the major coupling step and a Yamaguchi macrolactonization for ring closure.