60813-44-7Relevant academic research and scientific papers
Dry reaction on KF-alumina: Synthesis of 4-arylidene-1,3-(2H,4H) isoquinolinediones
Villemin, Didier,Martin, Benoit,Khalid, Mohamed
, p. 3195 - 3200 (1998)
1,2,3,4-Tetrahydroisoquinoline-1,3-dione (1) and arylcarboxyaldehydes (2) were condensed to 3-(arylmethylene)-1,2,3,4-tetrahydroisoquinoline-1,3- dione (3) in presence of potassium fluoride on alumina without solvent under focused microwave irradiation.
4-benzylideneisoquinoline-1,3(2H,4H)-diones as tyrosyl DNA phosphodiesterase 2 (TDP2) inhibitors
Senaweera, Sameera,He, Tianyu,Cui, Haixi,Aihara, Hideki,Wang, Zhengqiang
, p. 371 - 386 (2020/11/23)
Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase II (Top2) mediated DNA damages, including double-strand breaks (DSBs) that underpin the anticancer mechanism of clinical Top2 poisons such as etoposide (ETP). Inhibition of TDP2 could sensitize
