446-07-1

Usage

Uses

Used in Chemical Synthesis:
2'-Fluoro-5'-methylacetophenone is used as a key intermediate in the synthesis of various organic compounds. Its unique structure allows for the creation of a wide range of molecules with potential applications in different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2'-Fluoro-5'-methylacetophenone is used as a building block for the development of new drugs. Its chemical properties enable the formation of molecules with potential therapeutic effects, contributing to the advancement of medicine.
Used in Material Science:
2'-Fluoro-5'-methylacetophenone is employed in material science as a component in the development of novel materials with specific properties. Its incorporation into materials can lead to improved performance in various applications, such as electronics or coatings.
Used in Research and Development:
2'-Fluoro-5'-methylacetophenone is utilized in research and development settings to explore its potential applications and properties. Scientists and researchers use 2'-FLUORO-5'-METHYLACETOPHENONE to investigate its reactivity, stability, and interactions with other molecules, which can lead to new discoveries and innovations.

Upstream product

• 352-32-9 p-fluorotoluene 
• 75-36-5 acetyl chloride 
• 75-15-0 carbon disulfide 
• 7446-70-0 aluminium trichloride 
• 585-74-0 3-Methylacetophenone 

Downstream Products

• 486-81-7 2-(2-fluoro-5-methyl-phenyl)-6-methyl-quinoline-4-carboxylic acid 
• 391-21-9 6-chloro-2-(2-fluoro-5-methyl-phenyl)-quinoline-4-carboxylic acid 
• 391-20-8 6-bromo-2-(2-fluoro-5-methyl-phenyl)-quinoline-4-carboxylic acid 
• 62433-42-5 (2-chloro-phenyl)-[4-(2-fluoro-5-methyl-phenyl)-thiazol-2-yl]-amine 
• 845-00-1 [4-(2-fluoro-5-methyl-phenyl)-thiazol-2-yl]-phenyl-amine 
• 62433-41-4 (4-chloro-phenyl)-[4-(2-fluoro-5-methyl-phenyl)-thiazol-2-yl]-amine 
• 76475-86-0 3-Dimethylamino-1-(2-fluoro-5-methyl-phenyl)-propan-1-one; hydrochloride 
• 76475-89-3 1-(2-Fluoro-5-methyl-phenyl)-3-morpholin-4-yl-propan-1-one; hydrochloride 
• 76475-90-6 1-(2-Fluoro-5-methyl-phenyl)-3-piperidin-1-yl-propan-1-one; hydrochloride 
• 76475-91-7 1-(2-Fluoro-5-methyl-phenyl)-3-{4-[3-(2-fluoro-5-methyl-phenyl)-3-oxo-propyl]-piperazin-1-yl}-propan-1-one; hydrochloride 
• 79784-37-5 (2-Fluoro-5-methyl-phenyl)-oxo-acetaldehyde 
• 127055-74-7 (E)-3-(2-Chloro-phenyl)-1-(2-fluoro-5-methyl-phenyl)-propenone 
• 157429-20-4 C₁₀H₁₀FN₃OS 
• 2367-44-4 2-(2-fluoro-5-methyl-phenyl)-6-methyl-quinoline 

Relevant academic research and scientific papers

Pd-Catalysed direct C(sp2)-H fluorination of aromatic ketones: Concise access to anacetrapib

The Pd-cataylsed direct ortho-C(sp2)-H fluorination of aromatic ketones has been developed for the first time. The reaction features good regioselectivity and simple operations, constituting an alternative shortcut to access fluorinated ketones. A concise synthesis of anacetrapib has also been achieved by using late-stage C-H fluorination as a key step.

FLUORINE CONTAINING BIOACTIVE HETEROCYCLES PART III : SYNTHESIS OF SOME NEW FLUORINE CONTAINING PHENYLGLYOXALS AND 1,2,4-TRIAZINE DERIVATIVES

Some medicinally important new fluorine containing phenylglyoxals have been synthesized by selenium dioxide oxidation of appropriate fluorinated acetophenones and characterized by spectrum studies.The phenylglyoxals were treated with thiosemicarbazide to give corresponding thiosemicarbazones (III) which were cyclized, in situ, to yield 5-(fluorophenyl)-1,2,4-triazine-3(2H)-thiones.The 5-(4-fluorophenyl)-1,2,4-triazine-3-(2H)-thione (IV) undergoes nucleophilic displacement when refluxed with hydrazine hydrate to give corresponding 3-hydrazino-5-(4-fluorophenyl)-1,2,4-tria zine.The hydrazino derivative reacts with fluorinated 1,3-diketones, in glacial acetic acid yielding 5-(4-fluorophenyl)-3--1,2,4-triazines (VII).All synthesized compounds have been characterized on the basis of elemental analyses, ir, pmr and 19F nmr studies.