446-20-8

Basic information

• Product Name: 4-AMino-2-fluoro-5-nitroanisole[5-Fluoro-4-Methoxy-2-nitroaniline]
• Synonyms: 4-AMino-2-fluoro-5-nitroanisole[5-Fluoro-4-Methoxy-2-nitroaniline];4-Amino-2-fluoro-5-nitroanisole;5-Fluoro-4-methoxy-2-nitroaniline;NSC 1133;5-Fluoro-4-methoxy-2-nitro-phenylamine
• CAS NO: 446-20-8
• Molecular Formula: C₇H₇FN₂O₃
• Molecular Weight: 186.1404832
• Mol File: 446-20-8.mol

Chemical Properties

• Melting Point: 142.5-143.5 °C
• Boiling Point: 355.4°C at 760 mmHg
• Flash Point: 168.7°C
• Appearance: /
• Density: 1.412g/cm³
• Vapor Pressure: 3.14E-05mmHg at 25°C
• Refractive Index: 1.577
• PKA: -0.18±0.25(Predicted)
• CAS DataBase Reference: 4-AMino-2-fluoro-5-nitroanisole[5-Fluoro-4-Methoxy-2-nitroaniline](CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMino-2-fluoro-5-nitroanisole[5-Fluoro-4-Methoxy-2-nitroaniline](446-20-8)
• EPA Substance Registry System: 4-AMino-2-fluoro-5-nitroanisole[5-Fluoro-4-Methoxy-2-nitroaniline](446-20-8)

Safety Data

• Hazardous Substances Data: 446-20-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H7FN2O3/c1-13-7-3-6(10(11)12)5(9)2-4(7)8/h2-3H,9H2,1H3

Upstream product

• 366-99-4 3-fluoro-4-methoxyaniline 
• 452-15-3 N-(3-fluoro-4-methoxyphenyl)acetamide 
• 455-93-6 2-fluoro-1-methoxy-4-nitrobenzene 
• 321-28-8 1-fluoro-2-methoxybenzene 
• 448-26-0 N-(5-fluoro-4-methoxy-2-nitrophenyl)acetamide 

Downstream Products

• 76100-57-7 4,5-dimethyl-6-methoxy-8-<(4-amino-1-methylbutyl)amino>quinoline maleate 
• 76185-43-8 4-methyl-5-fluoro-6-methoxy-8-<(4-amino-1-methylbutyl)amino>quinoline maleate 
• 661463-13-4 4-bromo-2-fluoro-5-nitrophenyl methyl ether 
• 125163-15-7 4-Fluoro-5-methoxy-1,2-phenylenediamine 
• 170809-21-9 5-fluoro-6-methoxy-8-aminoquinoline 

Relevant articles and documents

Benzimidazole compound, and preparation method, intermediate and application thereof

The invention discloses a benzimidazole compound, and a preparation method, an intermediate and an application thereof. The invention provides a benzimidazole compound A or a pharmaceutically-acceptable salt thereof, and also provides an application of th

3,8-DIAZA-BICYCLO[4.2.0]OCT-3-YL AMIDES

The present invention relates to 3,8-diaza-bicyclo[4.2.0]oct-3-yl amide derivatives of formula (I), wherein the relative configuration of the diazabicyclooctane moiety is cis; and wherein Ar1, and Ar2 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.

COUMARIN DERIVATIVE AND USE THEREOF

The present invention relates to an alkaline earth metal salt or an organic amine salt of a compound represented by the formula [I]: wherein R1 and R2 are each a hydrogen atom, a halogen atom, or an optionally substituted linear hydrocarbon group; ring A is an optionally further substituted benzene ring; B is an optionally substituted benzene ring; R is a carboxyl group or a linear hydrocarbon group substituted with a carboxyl group and the like.

Positive allosteric modulators of the nicotinic acetylcholine receptor

The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals used to treat diseases or conditions in which α7 nAChR is known to be involved.

4-Methyl-5-(unsubstituted and substituted phenoxy)-6-methoxy-8-(aminoalkylamino)quinolines

Compounds of the class including 4-methyl-5-(unsubstituted and substitutedhenoxy)-6-methoxy-8-(aminoalkylamino)quinolines as the free bases and pharmaceutically acceptable acid amine salts are described. The compounds are highly effective antimalarial agents which possess, surprisingly, both tissue schizonticidal (radical curative) and blood schizonticidal (suppressive) activity. In addition, these drugs have significantly better therapeutics indices than primaquine which is the current tissue schizonticidal drug of choice. Primaquine possesses no useful blood schizonticidal activity at tolerated dose levels.