73943-41-6

Basic information

• Product Name: 2-FLUORO-6-METHOXYPHENOL
• Synonyms: 2-FLUORO-6-METHOXYPHENOL;2-Fluoro-6-methoxyphenol 98%;2-Fluoro-6-methoxyphenol98%;2-Hydroxy-3-fluoroanisole;2-Methoxy-6-fluorophenol
• CAS NO: 73943-41-6
• Molecular Formula: C₇H₇FO₂
• Molecular Weight: 142.13
• Product Categories: Phenol&Thiophenol&Mercaptan;Organic Building Blocks;Oxygen Compounds;Phenols
• Mol File: 73943-41-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 130-131 °C36 mm Hg(lit.)
• Flash Point: 218 °F
• Appearance: Clear colorless to light brown/Liquid
• Density: 1.23 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0627mmHg at 25°C
• Refractive Index: n20/D 1.52(lit.)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 8.71±0.10(Predicted)
• CAS DataBase Reference: 2-FLUORO-6-METHOXYPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-6-METHOXYPHENOL(73943-41-6)
• EPA Substance Registry System: 2-FLUORO-6-METHOXYPHENOL(73943-41-6)

Safety Data

• Hazard Codes: Xi,C
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 73943-41-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H7FO2/c1-10-6-4-2-3-5(8)7(6)9/h2-4,9H,1H3

Upstream product

• 446-59-3 2‐bromo‐1‐fluoro‐3‐methoxybenzene 
• 75626-21-0 C₉H₁₂BFO₃ 
• 443-81-2 2-bromo-3-fluorophenol 
• 148872-80-4 2-(benzyloxy)-3-fluorophenol 
• 914454-79-8 2-benzyloxy-3-fluoroanisole 
• 456-49-5 1-fluoro-3-methoxybenzene 
• 394-64-9 1-fluoro-2,3-dimethoxybenzene 

Downstream Products

• 1057322-67-4 5-chloro-2-(2-fluoro-6-methoxy-phenoxy)-3-nitro-pyridine 
• 79418-73-8 2-fluoro-3-hydroxy-4-methoxybenzaldehyde 
• 914454-91-4 2-(2-fluoro-6-methoxyphenoxy)ethylazide 
• 914454-97-0 2-(2-fluoro-6-methoxyphenoxy)ethylamine 
• 914454-85-6 2-(2-fluoro-6-methoxyphenoxy)-1-bromoethane 
• 394-64-9 1-fluoro-2,3-dimethoxybenzene 
• 103905-49-3 5-<(dimethylamino)methyl>-1-fluoro-2-hydroxy-3-methoxybenzene 
• 363-52-0 3-fluorocatechol 
• 313655-04-8 2-(2-Fluoro-6-methoxyphenoxy)ethyl 3-(1-Piperazinyl)-2-pyrazinyl Ether 
• 104716-83-8 6,7-Bis-benzyloxy-8-fluoro-1-(3,4,5-trimethoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline 
• 104716-81-6 2-(3,4-Bis-benzyloxy-5-fluoro-phenyl)-ethylamine 
• 104716-74-7 3-methoxy-4-hydroxy-5-fluorobenzyl cyanide 
• 104716-76-9 3,4-dihydroxy-5-fluorobenzyl cyanide 
• 104716-80-5 N-[2-(3,4-Bis-benzyloxy-5-fluoro-phenyl)-ethyl]-2-(3,4,5-trimethoxy-phenyl)-acetamide 

Relevant articles and documents

Phenyl acetate derivatives, fluorine-substituted on the phenyl group, as rapid recovery hypnotic agents with reflex depression

We report the synthesis of novel, potentially hypnotic fluorine-substituted phenyl acetate derivatives. We describe the structure-activity relationship that led us to the promising derivative: ethyl 2-(4-(2-(diethylamino)-2-oxoethoxy)-5-ethoxy-2-fluorophenyl) acetate (55). The unique pharmacological features of compound 55 are its relatively high affinity for the GABAA receptor, together with a unique affinity for the NMDA receptor, different to propanidid and AZD3043. In animal models, compound 55 showed stronger hypnotic potency and longer duration of LORR than propanidid and AZD3043, but also maintained a rapid recovery time to walking and behavioral recovery. In particular, compound 55 displayed reflex depression during infusion.

Facile and regioselective dealkylation of alkyl aryl ethers using niobium(V) pentachloride

A simple and facile method for the cleavage of carbon-oxygen bonds promoted by niobium pentachloride(V) is described. Excellent yields and regioselectivities were observed with various alkyl aryl ethers to give the phenols. NMR studies revealed the formation of monoaryloxy niobium salt(V), and a neighboring-group effect may play a significant role in the regioselectivity. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

6-PHENYL THIO- AND 6-CYCLOHEXYL THIO-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES

Mercapto substituted-2,3,4,5-tetrahydro-1H-3-benzazepines having dopamine receptor blocking activity are prepared from o-quinones or via standard preparative procedures.