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1,7,7-trimethylbicyclo[2.2.1]heptan-2-amine, also known as nornicotine or nornicotine amine, is an organic compound with the chemical formula C10H19N. It is a derivative of nicotine, a naturally occurring alkaloid found in the nightshade family of plants, and is structurally similar to nicotine but lacks one carbon atom. 1,7,7-trimethylbicyclo[2.2.1]heptan-2-amine is a colorless liquid with a pungent odor and is used as a research chemical and a precursor in the synthesis of various pharmaceuticals and agrochemicals. It is also known for its potential role in the formation of tobacco-specific nitrosamines, which are carcinogenic compounds found in tobacco products. Due to its potential health risks and legal restrictions, handling and use of 1,7,7-trimethylbicyclo[2.2.1]heptan-2-amine are subject to strict regulations.

4481-88-3

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4481-88-3 Usage

Molecular Weight

153.26 g/mol

Chemical Structure

A bicyclic amine with a nitrogen atom within a bicyclic ring system

Functional Groups

Bicyclic ring system
Amino group (-NH2)

Stereochemistry

Contains multiple stereocenters (1aR,2S,4S,5aR,5bS)

Physical State

Likely a solid at room temperature (based on molecular weight and structure)

Solubility

Soluble in organic solvents like ethanol, methanol, and dichloromethane

Reactivity

Can undergo reactions typical of amines, such as alkylation, acylation, and nucleophilic substitution

Uses

Building block for the synthesis of more complex organic compounds
Potential pharmaceutical applications
Under investigation for biological properties

Safety

As with many chemicals, appropriate safety measures should be taken when handling, such as using gloves and eye protection, and working in a well-ventilated area.

Check Digit Verification of cas no

The CAS Registry Mumber 4481-88-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,4,8 and 1 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 4481-88:
(6*4)+(5*4)+(4*8)+(3*1)+(2*8)+(1*8)=103
103 % 10 = 3
So 4481-88-3 is a valid CAS Registry Number.

4481-88-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,7,7-Trimethylbicyclo[2.2.1]heptan-2-amine

1.2 Other means of identification

Product number -
Other names isoborneol methyl ether

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4481-88-3 SDS

4481-88-3Relevant academic research and scientific papers

CYANO-PYRIMIDINE INHIBITORS OF EGFR/HER2

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Page/Page column 58-59, (2021/07/17)

Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with EGFR and/or HER2 activity.

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