448963-40-4

Upstream product

• 7693-46-1 4-Nitrophenyl chloroformate 
• 448963-33-5 C₃₀H₃₅N₇O₇ 
• 623-04-1 4-aminobenzenemethanol 
• 6464-78-4 (S)-2-((S)-2-benzyloxycarbonylamino-3-phenylpropanoylamino)-5-nitroguanidinopentanoic acid 
• 1161-13-3 N-Cbz-L-Phe 
• 3397-32-8 N-(benzyloxycarbonyl)-phenylalanine-N-hydroxysuccinimide ester 

Relevant academic research and scientific papers

Cathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin

A series of lysosomal protease-sensitive peptides attached to doxorubicin (DOX) was prepared as model substrates for internalizing anticancer immunoconjugates and potential antimetastasis prodrugs. Rates of cathepsin B-mediated release of free drug was measured for each, and human plasma stabilities for representative examples.