4512-97-4

Upstream product

• 84144-17-2 (2Z)-3-phenyl-3-(phenylselanyl)acrylic acid 
• 112763-72-1 1-(2-Methylselanyl-phenyl)-3-phenyl-propynone 
• 134419-77-5 1-(2-bromophenyl)-3-phenylprop-2-yn-1-one 
• 7154-66-7 2-bromobenzoic acid chloride 
• 1666-13-3 diphenyl diselenide 
• 70678-10-3 ethyl (Z)-3-phenyl-3-(phenylselanyl)acrylate 
• 2216-94-6 phenylpropynoic acid ethyl ester 
• 645-96-5 Benzeneselenol 
• 108-86-1 bromobenzene 
• 4671-91-4 4H-selenochromen-4-one 
• 6630-33-7 ortho-bromobenzaldehyde 
• 536-74-3 phenylacetylene 
• 89-98-5 2-chloro-benzaldehyde 
• 16619-64-0 1-(2-chlorophenyl)-3-phenyl-2-propyn-1-one 

Downstream Products

• 112763-72-1 1-(2-Methylselanyl-phenyl)-3-phenyl-propynone 
• 112763-71-0 3-methylselenaflavone 
• 49665-30-7 2-phenyl-4H-selenochromene 

Relevant academic research and scientific papers

Elemental chalcogen (Se, S) in PEG-400 to the synthesis of seleno- And thioflavones from 2-chlorophenyl ethynyl ketone and nucleophilic species of chalcogen

An alternative green method was developed for the synthesis of thio- and selenoflavones by the ring closure of 2-chlorophenyl ethynyl ketone with NaHY (Y = S, Se). These nucleophilic chalcogen species were generated in situ using NaBH4 to reduc

Stereoselective Synthesis of Z-Vinyl Selenides Through the Reaction of Sodium Selenide with Organic Halides and Alkynes

A practical synthetic approach to the stereoselective synthesis of Z-vinyl selenides is described through the reaction of sodium selenide with organic halides, followed by the addition to alkynes. The reaction conditions were also successfully applied to

A novel selenoflavone compound as anti-obesity agent

The present invention relates to a process for producing a novel selenoflavone compound and a pharmaceutical composition for preventing or treating obesity comprising the selenoflavone compound. In the present invention, selenoflavone, especially PMSF, which has never been synthesized due to synthetic difficulties can be synthesized through palladium-catalyzed direct C-H arylation. Since the synthesized selenoflavone has an improving effect related to activation of brown adipose tissue (BAT), the selenoflavone can be used in the composition for prevention and treatment of obesity.COPYRIGHT KIPO 2018

Efficient synthesis of polymethoxyselenoflavones via regioselective direct C-H arylation of selenochromones

Substantial research has suggested that the configuration and the total number of functional groups on flavones influence their bioactivity. To investigate the changes in the biological activities of selenoflavones in relationship to structural changes, the development of a generally applicable synthetic method was a key. Until now, an efficient pathway for palladium-catalyzed direct arylation with the selenocyclic enone systems is not known in the literature. We herein introduce a simple direct C-H arylation of two difficult coupling partners, selenochromones and electron-rich aryl bromide, affording diverse polymethoxyselenoflavones with great efficiency and high selectivity.

An alternative facile preparation of telluro- and selenochromones from o-bromophenyl ethynyl ketones

Treatment of o-bromophenyl ethynyl ketones 2 with sodium hydrogen telluride and selenide gave telluro- 3A and selenochromones 3B, respectively, in one pot via the presumed intermediates 4.

NEW SYNTHESIS OF CHALCOGENOCHROMONES

We describe a new synthesis of chalcogenochromones and of some of their oxygen, sulfur, selenium and tellurium derivatives.The synthesis involves acidic cyclisation of (o-alkylchalcogenophenyl) ethynyl ketones.

Regiochemical Control of the Addition of Aryl Selenols and Aryl Thiols to the Triple Bond of Arylpropiolates. Synthesis of Seleno- and Thioflavones and Seleno- and Thioaurones

Addition of aryl selenols and aryl thiols to arylpropiolates under basic conditions followed by saponification gave exclusively β-substituted cinnamates of predominant Z sterochemistry.Neat solutions of aryl selenols or aryl thiols and arylpropiolates aft