45159-25-9

Basic information

• Product Name: H-ALA-D-GLU-NH2
• Synonyms: L-ALA-D-ISOGLN;H-ALA-D-GLU-NH2;H-ALA-D-ISOGLN-OH;H-Ala-D-Glu-NH
• CAS NO: 45159-25-9
• Molecular Formula: C8H15N3O4
• Molecular Weight: 217.22
• Mol File: 45159-25-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• CAS DataBase Reference: H-ALA-D-GLU-NH2(CAS DataBase Reference)
• NIST Chemistry Reference: H-ALA-D-GLU-NH2(45159-25-9)
• EPA Substance Registry System: H-ALA-D-GLU-NH2(45159-25-9)

Safety Data

• Hazardous Substances Data: 45159-25-9(Hazardous Substances Data)

Usage

General Description

H-ALA-D-GLU-NH2 is a peptide consisting of the amino acids alanine (ALA), glutamic acid (GLU), and an amide group (NH2) at the C-terminus. It is a synthetic derivative of the naturally occurring peptide glutathione, which plays a crucial role in antioxidant defense. H-ALA-D-GLU-NH2 is used in research and pharmaceutical development for its potential to act as an antioxidant and to modulate cellular redox systems. It has also been investigated for its potential neuroprotective effects and therapeutic applications in conditions related to oxidative stress. This chemical entity has shown promise as a potential candidate for the development of novel drugs for various medical conditions.

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Relevant articles and documents

Ten-membered rings as key interaction motifs in folding of desmuramyl di-, tri-, and tetrapeptides

Muropeptides are fragments of polymeric peptidoglycan, unique constituent of bacterial cell walls, acting as immunostimulators (adjuvants). The smallest biologically active unit of peptidoglycan is N-acetylmuramyl-L-alanyl-D-isoglutamine. In this paper, the synthesis and conformational analysis of desmuramyl peptides, derivatives lacking the N-acetylmuramyl moiety, is described. Systematic conformational analysis (bottom-up approach) of peptides in zwitterionic and non-zwitterionic forms of corresponding desmuramyl di-, tri-, and tetrapeptides was performed and results were compared with experimental data obtained by NMR study. Ten-membered ring (C10, N1bH?O3) formed between isoGln amide group and C=O of AdGly was found to be a key interaction that constitutes the central structural spine and initiates β-turn-like folding in our model peptide systems.

Synthesis of muramyl dipeptide analogs with enhanced adjuvant activity

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