56772-92-0

Basic information

• Product Name: N-acetylisomuramyl-L-alanyl-D-isoglutamine
• CAS NO: 56772-92-0
• Molecular Weight: 492.483
• Mol File: 56772-92-0.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: N-acetylisomuramyl-L-alanyl-D-isoglutamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-acetylisomuramyl-L-alanyl-D-isoglutamine(56772-92-0)
• EPA Substance Registry System: N-acetylisomuramyl-L-alanyl-D-isoglutamine(56772-92-0)

Safety Data

• Hazardous Substances Data: 56772-92-0(Hazardous Substances Data)

Upstream product

• 35793-73-8 N-(tert-butyloxycarbonyl)-γ-benzyl-D-glutamic acid 
• 76420-28-5 N-acetyl-1-O-benzyl-4,6-O-benzylidene-α-isomuramyl-L-alanyl-D-isoglutamine benzyl ester 
• 87173-14-6 (R)-4-{(S)-2-[(R)-2-((2R,4aR,7R,8R,8aS)-7-Acetylamino-6-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy)-propionylamino]-propionylamino}-4-carbamoyl-butyric acid benzyl ester 
• 93218-76-9 N-acetyl-1-O-benzyl-4,6-O-benzylidenemuramoyl-L-alanyl-D-idoglutamine benzyl ester 
• 78062-11-0 1-O-benzyl-N-acetyl-muramyl-L-alanyl-D-isoglutamine 
• 78246-81-8 benzyl 2-acetamido-4,6-O-benzylidene-2-deoxy-α-D-glucopyranoside 
• 13343-62-9 benzyl 2-acetamido-2-deoxy-α-D-glucopyranoside 
• 7512-17-6 N-Acetyl-D-glucosamine 
• 73089-68-6 benzyl 2-acetamido-4,6-O-benzylidene-3-O-[(R)-1-carboxyethyl]-2-deoxy-α-D-glucopyranoside 
• 62928-83-0 benzyl (R)-4-((S)-2-((R)-2-(((2S,3R,4R,5S,6R)-3-acetamido-2-(benzyloxy)-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)oxy)propanamido)propanamido)-5-amino-5-oxopentanoate 
• 112897-97-9 (E)-3-(3,4-difluorophenyl)acrylic acid 
• 459-32-5 (E)-4-fluorocinnamic acid 
• 174603-37-3 3-(2-chloro-4-fluorophenyl)-2-propenoic acid 
• 312693-55-3 (E)-3-(4-chloro-2-fluoro-phenyl)prop-2-enoic acid 

Downstream Products

• 1856-93-5 (R)-2-(((3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)oxy)propanoic acid 
• 45159-25-9 L-alanyl-D-isoglutamine 
• 87137-44-8 C₄₂H₄₂N₈O₁₇^(2-)*2Na⁽¹⁺⁾ 

Relevant articles and documents

Further Insights on Structural Modifications of Muramyl Dipeptides to Study the Human NOD2 Stimulating Activity

A series of muramyl dipeptide (MDP) analogues with structural modifications at the C4 position of MurNAc and on the d-iso-glutamine (isoGln) residue of the peptide part were synthesized. The C4-diversification of MurNAc was conveniently achieved by using CuAAC click strategy to conjugate an azido muramyl dipeptide precursor with structurally diverse alkynes. d-Glutamic acid (Glu), replaced with isoGln, was applied for the structural diversity through esterification or amidation of the carboxylic acid. In total, 26 MDP analogues were synthesized and bio-evaluated for the study of human NOD2 stimulation activity in the innate immune response. Interestingly, MDP derivatives with an ester moiety are found to be more potent than reference compound MDP itself or MDP analogues containing an amide moiety. Among the varied lengths of the alkyl chain in ester derivatives, the MDP analogue bearing the d-glutamate dodecyl (C12) ester moiety showed the best NOD2 stimulation potency.

Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate

The present invention discloses chemical synthesis, anti-tumor and anti-metastatic effects of a dual functional conjugate as shown by formula I. Specifically, paclitaxel or docetaxol is linked with muramyl dipeptide derivative to form a conjugate, thus dual anti-tumor and anti-metastatic effects are achieved by combination of chemotherapy and immunotherapy. The present invention also discloses that paclitaxel or docetaxol and muramyl dipeptide derivative conjugate is synthesized by combination of solid-phase and solution-phase synthesis, and said conjugate can be used in manufacture of anti-tumor medicaments as proved by reliable bioassays.

DENTAL FILLING REPAIR KIT

Provided is a filling/restoring material, including a photopolymerization initiator of a quaternary system formed by combining an a-diketone compound, an aliphatic amine compound, an aromatic amine compound, and a photoacid generator, in which even when the filling/restoring material is filled and cured on a cured layer of a dental adhesive material including a radical-polymerizable monomer having an acidic group, the filling/restoring material undergoes sufficient curing up to a contact interface between the filling/restoring material and the cured layer, thereby providing high adhesive strength stably. Also provided is a dental filling/restoration kit, including: a filling/restoring material (A) including: a polymerizable monomer having no acidic group (I); a basic inorganic material (II); and a photopolymerization initiator (III) formed by at least combining: an a-diketone compound (i); an aliphatic amine compound (ii); an aromatic amine compound (iii) ; and a photoacid generator (iv); and an adhesive material (B), which is used for adhesion between a tooth and the filling/restoring material by curing the adhesive material before filling the filling/restoring material, the adhesive material including: a polymerizable monomer including a polymerizable monomer having an acidic group (I); and a polymerization initiator (II).