4519-47-5

Upstream product

• 67-56-1 methanol 
• 80-63-7 methyl 2-chloroacrylate 
• 62-53-3 aniline 
• 4519-46-4 methyl 2-bromoacrylate 

Downstream Products

• 4519-51-1 α-chlorocinnamic acid methyl ester 
• 14737-94-1 methyl 2-chloro-3-phenylprop-2(Z)-enoate 
• 5556-23-0 3-Hydroxy-5-phenyl-thiophen-2-carbonsaeure-methylester 

Relevant academic research and scientific papers

Stereoselective dehydrobromination of alkyl α-Br α-Cl-carboxylates

(Z)-Alkyl α-Cl-α,β-unsaturated esters are prepared in excellent yields by stereoselective dehydrobromination of alkyl α-Br-α-Cl-carboxylates with LiCl-Li2CO3 in dimethylformamide.

Bromoarylation of Methyl 2-Chloroacrylate under Meerwein Conditions for the Synthesis of Substituted 3-Hydroxythiophenes

Methyl 3-aryl-2-bromo-2-chloropropanoates can be prepared by Meerwein reaction from methyl 2-chloroacrylate and various arenediazonium salts under copper(II) bromide catalysis. The resulting readily available compounds were used as starting materials in reactions with substituted methanethiols for the construction of substituted 3-hydroxythiophenes which have not yet been accessible by other routes. Structural variety of the obtained 2-substituted 5-aryl-3-hydroxythiophenes has been achieved due to a wide range of available starting materials, including both anilines and thiols.