452323-32-9Relevant academic research and scientific papers
De novo design, synthesis and evaluation of a non-steroidal diphenylnaphthyl propylene ligand for the estrogen receptor
Schmidt, Jonathan M.,Mercure, Julie,Tremblay, Gilles B.,Page, Martine,Feher, Miklos,Dunn-Dufault, Robert,Peter, Markus G.,Redden, Peter R.
, p. 1389 - 1396 (2003)
There is still a strong need for additional diversity and new chemical scaffolds to allow for the exploration of improved tissue selectivity and finding better selective estrogen receptor modulators (SERMs). Using a de novo design technology a diphenylnap
1,2-diphenyl-1-naphthyl ethene derivatives, analogs and use thereof
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, (2008/06/13)
Molecules demonstrating anti-proliferative effects against epithelial cancer cell lines, human estrogen-dependent cancer cells and endothelial cells are disclosed. The molecules are intended for use in therapeutic preparations for the treatment of various
