74684-47-2

Upstream product

• 64-17-5 ethanol 
• 74684-45-0 (E)-1-Anisyl-2-(p-nitrophenyl)propen-1-yl chloride 
• 74684-46-1 (Z)-1-Anisyl-2-(p-nitrophenyl)propen-1-yl chloride 
• 75-89-8 2,2,2-trifluoroethanol 
• 20765-22-4 1-(4-methoxyphenyl)-2-(4-nitrophenyl)ethanone 
• 74-88-4 methyl iodide 
• 19910-33-9 2-(4-nitrophenyl)propanoic acid 
• 100-66-3 methoxybenzene 
• 104-03-0 4-nitrobenzeneacetic acid 

Downstream Products

• 74684-48-3 1-(p-Methoxyphenyl)-1,1,2-trichloro-2-(p-nitrophenyl)-propane 
• 5912-94-7 1-(4-Methoxy-phenyl)-2-(4-nitro-phenyl)-propan-1-ol 
• 452323-32-9 1-(4-methoxyphenyl)-2-(4-aminophenyl)-1-propanone 
• 25017-89-4 1-(4-methoxyphenyl)-2-(4-hydroxyphenyl)-1-propanone 
• 452323-33-0 1-(4-methoxyphenyl)-2-(4-(2-chloroethoxy)phenyl)-1-propanone 
• 452323-39-6 1-(4-methoxyphenyl)-2-(4-(2-pyrrolidin-1-yl-ethoxy)phenyl)-1-propanone 
• 5912-83-4 trans-4'-Methoxy-α-methyl-4-nitro-stilben 

Relevant academic research and scientific papers

De novo design, synthesis and evaluation of a non-steroidal diphenylnaphthyl propylene ligand for the estrogen receptor

There is still a strong need for additional diversity and new chemical scaffolds to allow for the exploration of improved tissue selectivity and finding better selective estrogen receptor modulators (SERMs). Using a de novo design technology a diphenylnap

1,2-diphenyl-1-naphthyl ethene derivatives, analogs and use thereof

Molecules demonstrating anti-proliferative effects against epithelial cancer cell lines, human estrogen-dependent cancer cells and endothelial cells are disclosed. The molecules are intended for use in therapeutic preparations for the treatment of various

Vinylic Cations from Solvolysis. 33. Solvolysis of (E)- and (Z)-1-Anisyl-2-(p-nitrophenyl)propen-1-yl chlorides

The solvolysis of (E)- and (Z)-1-anisyl-2-p-nitrophenylpropen-1-yl chlorides (4-E and 4-Z) in buffered aqueous EtOH, TFE, and aqueous TFE was studied.The products in aqueous EtOH are a 6:4 ratio of the ethers 9-E and 9-Z and 1-anisyl-2-(p-nitrophenyl)-1-propanone (6), and in TFE a 7:3 ratio of the trifluoroethyl ethers 11-E and 11-Z and 6 are formed. The Grunwald-Winstein m values at 120 deg C in aqueous EtOH are 0.53 (4-E) and 0.62 (4-Z) and in aqueous TFE are 0.98 (4-E) and 0.88 (4-Z).In aqueous EtOH, common-ion rate depression and a 4-E 4-Z isomerization during the solvolysis are negligible, whereas in TFE and less so in aqueous TFE strong common-ion rate depression and an extensive isomerization, which give an equilibrium ratio of 66:34 4-E/4-Z, accompany the solvolysis.In 80percent EtOH/p-MeC6H4S(1-) the reaction is of second order, the products are a 6:4 ratio of the vinyl thiolates 12-E and 12-Z, and a rapid 4-E 4-Z isomerization takes place.In TFE containing CF3CH2O(1-) or p-MeC6H4S(1-) neither isomerization nor common-ion rate depression were observed, and the reactions were several times faster than in TFE/2,6-luitidine.An ionization to a cationoid species is suggested in all cases except in 80percent EtOH/RS(1-).In aqueous EtOH the reaction probably proceeds via the ion pairs 24a and 24b, whose capture by the solvent is slower than their interconversion but faster than internal return. In TFE a long-lived and selective free vinyl cation, 23, is formed. Preferential capture of the Cl(1-) over the solvent occurs from the less hindered side of 23, resulting in common-ion rate depression and isomerization. In the presence of the stronger nucleophiles RO(1-) and RS(1-), the capture occurs at the ion-pair stage. In 80percent EtOH/p-MeC6H4S(1-) the mechanism is probably a nucleophilic substitution via a carbanionic intermediate, but the isomerization follows a different route, probably a reversible electron-transfer process.