4530-17-0

Basic information

• Product Name: t-butoxycarbonyl-glycyl-phenylalanine
• Synonyms: t-butoxycarbonyl-glycyl-phenylalanine
• CAS NO: 4530-17-0
• Molecular Weight: 322.361
• Mol File: 4530-17-0.mol

Chemical Properties

• CAS DataBase Reference: t-butoxycarbonyl-glycyl-phenylalanine(CAS DataBase Reference)
• NIST Chemistry Reference: t-butoxycarbonyl-glycyl-phenylalanine(4530-17-0)
• EPA Substance Registry System: t-butoxycarbonyl-glycyl-phenylalanine(4530-17-0)

Safety Data

• Hazardous Substances Data: 4530-17-0(Hazardous Substances Data)

Upstream product

• 13303-10-1 tert-Butyl 4-nitrophenyl carbonate 
• 721-66-4 glycylphenylalanine 
• 4530-20-5 BOC-glycine 
• 2577-90-4 L-phenylalanine methyl ester 

Downstream Products

• 74974-42-8 (S)-trans-5-t-butoxycarbonylamino-6-(4-t-butoxyphenyl)-hex-3-enoylglycyl-L-phenylalanyl-L-leucine methyl ester 
• 74974-43-9 (S)-trans-5-amino-6-(4-hydroxyphenyl)hex-3-enoylglycyl-L-phenylalanyl-L-leucine 
• 128228-55-7 C₁₆H₂₀N₂O₄ 
• 124194-31-6 Boc-Gly-Δ^ZPhe azlactone 
• 3982-70-5 N-t-butoxycarbonylglycyl-L-phenylalanyl-L-leucine methyl ester 
• 106624-70-8 methyl 2-(2-(tert-butoxycarbonylamino)acetamido)-3-phenylpropanoate 

Relevant articles and documents

On the Double Bond Isostere of the Peptide Bond: Preparation of an Enkephalin Analogue

Methodology for preparing dipeptide analogues in which a carbon -carbon double bond replaces the normal amide bond is described.Thus, the protected tyrosylglycine analogue, (S)-trans-5-t-butyloxycarbonylamino-6-(4-t-butoxyphenyl)hex-3-enoic acid has been synthesised and incorporated into the Leu-enkephalin analogue (3) by condensation with glycylphenylalanyl-leucine.The enkephalin analogue retained biological activity.The significance of this isosteric replacement of the amide group is discussed.