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L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-D-phenylalanyl]-, methyl ester is a complex organic compound with the chemical formula C21H31N2O5. It is a derivative of the amino acid L-leucine, featuring a methyl ester group and a protected glycine residue. L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-D-phenylalanyl]-, methyl ester is often used in peptide synthesis, particularly in the preparation of pharmaceuticals and other bioactive molecules. The structure includes a leucine unit, a phenylalanine unit, and a glycine unit, with the latter two being connected through a carbonyl group and protected by a 1,1-dimethylethoxy group. This protection is crucial for preventing unwanted side reactions during peptide bond formation. The compound's ester group allows for controlled hydrolysis, which is essential for the controlled release of the peptide in biological systems.

3982-70-5

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3982-70-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3982-70-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,9,8 and 2 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 3982-70:
(6*3)+(5*9)+(4*8)+(3*2)+(2*7)+(1*0)=115
115 % 10 = 5
So 3982-70-5 is a valid CAS Registry Number.

3982-70-5Relevant academic research and scientific papers

SYNTHESIS OF CHIRAL OLIGOPEPTIDES BY MEANS OF CATALYTIC ASYMMETRIC HYDROGENATION OF DEHYDROPEPTIDES

Ojima, Iwao,Yoda, Noriko,Yatabe, Momoko,Tanaka, Toshiyuki,Kogure, Tetsuo

, p. 1255 - 1268 (2007/10/02)

Asymmetric hydrogenation of Ac-ΔTyr(Ac)-(S)-Ala-Gly-OMe (6), Ac-ΔTyr(Ac)-(R)-Ala-Gly-(S)-Phe-OMe (7), Ac-ΔPhe-NH-CH(R)-CH2-OCH2Ph (10), HCO-ΔPhe-(S)-Leu-OMe (16), X-AA-ΔPhe-AA'-OMe ( 5: X=tBOC, CBZ, CF3CO; AA, AA'= α-amino acid ), and t

On the Double Bond Isostere of the Peptide Bond: Preparation of an Enkephalin Analogue

Hann, Michael M.,Sammes, Peter G.,Kennewell, Peter D.,Taylor, John B.

, p. 307 - 314 (2007/10/02)

Methodology for preparing dipeptide analogues in which a carbon -carbon double bond replaces the normal amide bond is described.Thus, the protected tyrosylglycine analogue, (S)-trans-5-t-butyloxycarbonylamino-6-(4-t-butoxyphenyl)hex-3-enoic acid has been synthesised and incorporated into the Leu-enkephalin analogue (3) by condensation with glycylphenylalanyl-leucine.The enkephalin analogue retained biological activity.The significance of this isosteric replacement of the amide group is discussed.

SYNTHESIS OF CHIRAL TRIPEPTIDES BY ASYMMETRIC HYDROGENATION OF DEHYDROPEPTIDES. REMARKABLE EFFECTS OF N-PROTECTING GROUPS ON STEREOSELECTIVITY AND REACTIVITY

Ojima, Iwao,Yoda, Noriko

, p. 3913 - 3916 (2007/10/02)

Dehydrotripeptides, X-CH(Ri)-ΔPhe-CH(Rk)COOMe (3: X = tBOC-NH, CBZ-NH, CF3CONH and N3), were employed for the asymmetric hydrogenation catalyzed by chiral rhodium complexes and it was found that tBOC-3 brought a

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