4539-70-2

Usage

Uses

Used in Food Industry:
Lecithindistearoyl is used as an emulsifier and stabilizer for [helping to mix ingredients that would otherwise separate, such as oil and water]. This is particularly important in the production of food products where a uniform texture and consistency are desired.
Used in Cosmetic and Personal Care Industry:
Lecithindistearoyl is used as a surfactant in [enhancing the texture and consistency of cosmetic and personal care products]. Its ability to improve the product's feel and appearance makes it a popular ingredient in these formulations.

InChI:InChI=1/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3

Upstream product

• 51063-97-9 DL-α,β-distearin 
• 111-63-7 vinyl stearate 
• 34688-34-1 glycerolcholine phosphate 
• 57-11-4 stearic acid 
• 24529-89-3 3-hydroxypropane-1,2-diyl (9Z,9’Z,12Z,12’Z)-bis(octadeca-9,12-dienoate) 
• 59573-98-7 Octadecanoic acid 1-octadecanoyloxymethyl-2-(2-oxo-2λ⁵-[1,3,2]dioxaphospholan-2-yloxy)-ethyl ester 
• 75-50-3 trimethylamine 
• 18498-22-1 DL-1.2-Distearoyl-glycerin-phosphorsaeure-⁽³⁾-mono-2-brom-aethylester 
• 4167-02-6 2-bromoethylphosphoric acid dichloride 
• 6542-05-8 1,2-Dilinoleoyl-sn-glycerol-3-phosphorylcholine 
• 107437-06-9 α-<α'-Linoleoyl-β-stearoyl>-phosphatidylcholin 
• 55357-38-5 choline tosylate 
• 106654-97-1 α-<α'-Linoleoyl-β-stearoyl>-phosphadidyl-ethylenbromhydrin 
• 67-48-1 choline chloride 

Downstream Products

• 17364-19-1 1-stearoyl-sn-glycero-3-phosphocholine 
• 67-48-1 choline chloride 
• 18892-74-5 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine 
• 6753-53-3 1-octadecanoyl-2-[cis-9,12]-octadecadienoyl-glycero-3-phosphocholine 

Relevant academic research and scientific papers

Method for preparing difatty acyl phosphatidylcholine by solid-phase reaction

The invention relates to a method for preparing difatty acyl phosphatidylcholine by a solid-phase reaction. Glycerol phosphatidylcholine is subjected to wet-process loading by using a high-activity solid adsorbent, and then a condensation reaction is carried out on the glycerol phosphatidylcholine with fatty acid to obtain the difatty acyl phosphatidylcholine. The method comprises the following steps: dissolving glyceryl phosphatidylcholine in an organic solvent, adding a high-activity solid adsorbent, carrying out adsorbing dispersion while stirring, removing the organic solvent by vacuum evaporation, and carrying out vacuum drying on the obtained solid-phase loaded mixed material; dissolving fatty acid in an organic solvent, adding a condensation coupling agent, carrying out heating reflux to prepare active ester of fatty acid, adding the solid-phase loaded glyceryl phosphatidylcholine, and continuing reflux to prepare a difatty acyl phosphatidylcholine crude product; and carrying out filtering to recover the high-activity solid adsorbent, desolventizing mother liquor, pulping a crude product by using an organic solvent, and carrying out recrystallizing to obtain the high-puritydifatty acyl phosphatidylcholine. According to the method, the reaction yield reaches 65% or above, the product purity reaches 99% or above, the process is simple, the production period is short, andindustrial production is easy to achieve.

1,2-Diacrylglycerol and wherein the intermediate preparation method

The invention discloses a preparation method for diacylglycero and an intermediate thereof. The preparation method for diacylglycero comprises the following steps: in an ether solvent and/or an alcohol solvent, in the present of an alkali, performing hydrolysis reaction on a compound shown as a formula 5, so as to obtain diacylglycero which is 1 shown in a formula 1. R in the formula 5 and 5 is C14-C18 saturated or unsaturated aliphatic acyl. The preparation method is cheap in raw materials, mild in reaction conditions, safe in operation, simple in postprocessing operation, high in reaction conversion rate, high in yield and suitable for large-scale production.

Process for the production of phospholipids

A new enzymatic process for preparing 1,2-diacylated phospholipids using an enzyme preparation possessing phospholipase activity towards acylation at the sn-1 and sn-2 sites in a microaqueous reaction system. More particularly, the 1,2-diacyl-phospholipids produced according to the esterification/transesterification process are obtainable in high yield and purity and carry identical desired carboxylic acid, preferably fatty acid, acyl groups at the sn-1 and sn-2 positions. The process involves esterification/transesterification (acylation) of a glycerophospholipid, preferably glycerophosphoryl choline (GPC) with a desired carboxylic acid, preferably fatty acid, or their derivatives in the presence of the above mentioned appropriate enzyme preparation. The process of the invention further relates to a process for the production of 1-acyl-2-lyso-glycerophospholipid, preferably 2-lyso-PC by reacting glycerophospholipid, preferably glycerophosphoryl choline (GPC) with a desired carboxylic acid, preferably fatty acid, or their derivatives in the presence of a sn-1 specific phospholipase (PLA1 or PLA1,2) and a solvent, in a microaqueous medium.

Method for loading lipid vesicles

Methods for the preparation of stable liposome formulations of protonatable therapeutic agents. The methods involve loading a therapeutic agent into preformed liposomes having a methylamine concentration gradient across the lipid bilayer of the liposomes. These methods provide liposome formulations which are more stable, more cost effective, and easier to prepare in a clinical environment than those previously available. The present invention also provides the pharmaceutical compositions prepared by the above methods, a kit for the preparation of liposome formulations of therapeutic agents, and methods for their use.

Composition and method for treatment of disseminated fungal infections in mammals

A method is disclosed for treatment of disseminated fungal infection in a mammal comprising the administration of a fungicidally effective amount of Amphotericin B encapsulated in a substantially sterol-free liposome to the infected mammal. Also provided is an agent for treatment of disseminated fungal infection in a mammal comprising Amphotericin B encapsulated in a liposome which consists essentially of lipids other than sterols.

Complexes of saponins with phospholipids and pharmaceutical and cosmetic compositions containing them

Complexes of saponins with natural or synthetic phospholipids have high lipophilia and improved bio-availability and are suitable for use as the active principle in pharmaceutical, dermatologic and cosmetic compositions.

Viral liposome particle

The outer membrane of influenza virus is attached to a liposome by two different techniques. In addition, one of the techniques allows the entrapment of intact virus, usually one virus per liposome. The techniques can be performed with either influenza virus A or B.