Cuscohygrine, also known as Datura alkaloid, is a primary alkaloid derived from medicinal plants such as Datura metel. It is characterized by its clear, colorless oil appearance and exhibits unique chemical properties that make it a promising candidate for various applications in different industries.

454-14-8

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Basic information
1. Product Name: Cuscohygrine
2. Synonyms: 1,3-bis[(2s)-1-methylpyrrolidin-2-yl]propan-2-one;cuscohygrine;1,3-bis(1-methyl-2-pyrrolidinyl)acetone;1,3-BIS(1-METHYL-2-PYRROLIDINYL)PROPANONE;Cuskhygrine;Hellaradine;1,3-Bis[1-methylpyrrolidin-2-yl]propan-2-one;C06521
3. CAS NO:454-14-8
4. Molecular Formula: C₁₃H₂₄N₂O
5. Molecular Weight: 224.34246
6. EINECS: N/A
7. Product Categories: Heterocycles
8. Mol File: 454-14-8.mol
Chemical Properties
1. Melting Point: N/A
2. Boiling Point: bp23 169-170°; bp14 152°; bp2 118-125°
3. Flash Point: 118 °C
4. Appearance: /
5. Density: d420 0.9733
6. Vapor Pressure: 0.000531mmHg at 25°C
7. Refractive Index: nD20 1.4832
8. Storage Temp.: -20?C Freezer
9. Solubility: Chloroform (Soluble), Ethyl Acetate, Methanol (Slightly)
10. Stability: Solutions are unstable.
11. CAS DataBase Reference: Cuscohygrine(CAS DataBase Reference)
12. NIST Chemistry Reference: Cuscohygrine(454-14-8)
13. EPA Substance Registry System: Cuscohygrine(454-14-8)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: N/A
4. WGK Germany:
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 454-14-8(Hazardous Substances Data)

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Uses

Used in Pharmaceutical Industry:
Cuscohygrine is used as an active pharmaceutical ingredient for its medicinal properties. It is particularly effective in traditional medicine, where it has been used for centuries to treat various ailments due to its potent alkaloid content.
Used in Chemical Industry:
Cuscohygrine is used as a chemical intermediate for the synthesis of other compounds and pharmaceuticals. Its clear, colorless oil form makes it suitable for use in the chemical industry, where it can be further processed and utilized in the creation of various products.
Used in Research and Development:
Due to its unique chemical properties and potential applications, Cuscohygrine is also used in research and development for the discovery of new drugs and therapies. Its study can lead to a better understanding of its mechanisms of action and potential uses in modern medicine.

Check Digit Verification of cas no

The CAS Registry Mumber 454-14-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,5 and 4 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 454-14:
(5*4)+(4*5)+(3*4)+(2*1)+(1*4)=58
58 % 10 = 8
So 454-14-8 is a valid CAS Registry Number.

InChI:InChI=1/C13H24N2O/c1-14-7-3-5-11(14)9-13(16)10-12-6-4-8-15(12)2/h11-12H,3-10H2,1-2H3

454-14-8Synthetic route

: 872-50-4
1-methyl-pyrrolidin-2-one

: 542-05-2
acetonedicarboxylic acid

: 454-14-8
cuscohygrine

Conditions	Yield
With palladium; acetic acid Hydrogenation;
With acetic acid; platinum Hydrogenation;

Conditions	Yield
With hydrogenchloride at 180℃;
With potassium hydroxide; diethyl ether laengeres Stehen;
With potassium hydroxide 8-stdg. Kochen;

Conditions	Yield
With sodium amalgam; water isomer(ic) II;
With ethanol; sodium at 80℃; Trennung ueber das Pikrat; isomer(ic) II;

Conditions	Yield
With sodium amalgam; water isomer(ic) I;
With ethanol; sodium at 80℃; Trennung von der β-Form ueber das Pikrat; isomer(ic) I;

454-14-8

Basic information

Chemical Properties

Safety Data

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454-14-8 Usage

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Check Digit Verification of cas no

454-14-8Synthetic route

454-14-8Upstream product

454-14-8Downstream Products

454-14-8Relevant academic research and scientific papers