454-55-7Relevant academic research and scientific papers
TRPA1 ANTAGONISTS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH PAIN AND INFLAMMATION
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Page/Page column 29, (2021/11/26)
The present invention is directed to compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions comprising said compounds,
Trifluoromethylation of Unactivated Alkenes with Me3SiCF3 and N-Iodosuccinimide
Yang, Xinkan,Tsui, Gavin Chit
supporting information, p. 1521 - 1525 (2019/03/07)
A novel approach to the trifluoromethylation of unactivated alkenes is presented. This reaction is promoted by N-iodosuccinimide (NIS) under visible light irradiation without the need for photocatalysts. The mild conditions allow the direct synthesis of u
The modified trifluoromethylation protocol applicable to electronically deficient iodopyridinones
Kawasaki-Takasuka, Tomoko,Yamazaki, Takashi
, p. 6824 - 6831 (2015/08/24)
Utilization of a mixed solvent system of DMF/HMPA=1/1 (v/v) to the KF/CuI/TMSCF3 reagent system proved to significantly affect the reaction, realizing convenient introduction of a trifluoromethyl (CF3) group not only to electron-deficient iodopyridinones with quite a few previous successful examples but also to aliphatic vinylic iodides.
Copper-mediated trifluoromethylation of aryl-, heteroaryl-, and vinyltrifluoroborates with Langlois' reagent
Dubbaka, Srinivas Reddy,Salla, Manohar,Bolisetti, Raghu,Nizalapur, Shashidhar
, p. 6496 - 6499 (2014/02/14)
An effortless and realistic procedure for the copper-mediated trifluoromethylation of aryl-, heteroaryl- and vinyltrifluoroborates with CF3 radicals generated from NaSO2CF3 and tert-butyl hydroperoxide (TBHP) is presented. The developed method produces trifluoromethyl arenes and -alkenes in good to excellent yields and a wide range of electronically and structurally diverse substrates are tolerated.
Trifluoromethylation of alkenes by visible light photoredox catalysis
Iqbal, Naeem,Choi, Sungkyu,Kim, Eunjin,Cho, Eun Jin
, p. 11383 - 11387 (2013/03/13)
A method for trifluoromethylation of alkenes has been developed employing visible light photoredox catalysis with CF3I, Ru(Phen) 3Cl2, and DBU. This process works especially well for terminal alkenes to give alkenyl-CF3 products with only E-stereochemistry. The mild reaction conditions enable the trifluoromethylation of a range of alkenes that bear various functional groups.
The palladium-catalyzed trifluoromethylation of vinyl sulfonates
Cho, Eun Jin,Buchwald, Stephen L.
supporting information; experimental part, p. 6552 - 6555 (2012/01/15)
A method for the palladium-catalyzed trifluoromethylation of cyclohexenyl sulfonates has been developed. Various cyclohexenyl triflates and nonaflates underwent trifluoromethylation under mild reaction conditions using a catalyst system composed of Pd(dba
Convenient synthesis of fluorinated alkanes and cycloalkanes by hydrogenation of perfluoroalkylalkenes under ultrasound irradiation
Carcenac,Tordeux,Wakselman,Diter
, p. 1347 - 1355 (2007/10/03)
Synthesis of several 1,4-disubstituted cyclohexanes, by hydrogenation of sterically hindered and electron poor perfluoroalkyl alkenes, was performed, at room temperature under hydrogen at atmospheric pressure. Hydrogenation was difficult to achieve without ultrasound whatever catalyst and pressure (from 1 to 120 bar) used. Coupling of ultrasonic irradiation with metallic catalysis dramatically increased the efficiency of hydrogenation of perfluoroalkyl alkenes.
Fluorination of Unsaturated Aldehydes with Sulfur Tetrafluoride
Haas, Alois,Pluemer, Rita,Schiller, Achim
, p. 3004 - 3010 (2007/10/02)
Fluorination of unsaturated aldehydes 1 with SF4 in the presence of KF at 20 deg C leads to the corresponding difluoromethyl-substituted compounds 2 in various yields.Dehydrohalogenation of 1-bromo-1-(difluoromethyl)- (2b) or 1-bromo-1-(trifluoromethyl)cy
