454186-08-4

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 2973-78-6 3-bromo-4-hydroxybenzylaldehyde 
• 191602-84-3 3-bromo-4-iso-propoxybenzaldehyde 

Downstream Products

• 1254062-52-6 2-bromo-4-bromomethyl-1-isopropoxybenzene 
• 454186-06-2 8-{4-[2-(ethoxycarbonyl-methyl-amino)-ethyl]-2-nitro-phenoxy}-1-[4-(2-isopropoxy-5-methoxycarbonyl-phenoxy)-benzyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 454185-87-6 3-[4-((S)-8-{4-[2-(Ethoxycarbonyl-methyl-amino)-ethyl]-2-methoxy-phenoxy}-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-phenoxy]-4-isopropoxy-benzoic acid methyl ester 
• 454185-99-0 N-[2-(3-benzyloxy-4,5-dimethoxy-phenyl)-ethyl]-2-{4-[5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenoxy]-phenyl}-N-(1-phenyl-ethyl)-acetamide 
• 454186-14-2 3-{4-[(S)-6,7-Dimethoxy-8-(6-methoxy-2-methyl-1-oxo-1,2,3,4-tetrahydro-isoquinolin-7-yloxy)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl]-phenoxy}-4-isopropoxy-benzoic acid methyl ester 
• 454186-03-9 3-{4-[(S)-8-Benzyloxy-6,7-dimethoxy-2-((S)-1-phenyl-ethyl)-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl]-phenoxy}-4-isopropoxy-benzoic acid methyl ester 
• 454186-01-7 3-(4-{[[2-(3-Benzyloxy-4,5-dimethoxy-phenyl)-ethyl]-((S)-1-phenyl-ethyl)-carbamoyl]-methyl}-phenoxy)-4-isopropoxy-benzoic acid 
• 454186-12-0 3-(4-{[[2-(3-Benzyloxy-4,5-dimethoxy-phenyl)-ethyl]-((S)-1-phenyl-ethyl)-carbamoyl]-methyl}-phenoxy)-4-isopropoxy-benzoic acid methyl ester 
• 454186-11-9 N-[2-(3-benzyloxy-4,5-dimethoxy-phenyl)-ethyl]-2-[4-(5-hydroxymethyl-2-isopropoxy-phenoxy)-phenyl]-N-(1-phenyl-ethyl)-acetamide 
• 454186-00-6 N-[2-(3-benzyloxy-4,5-dimethoxy-phenyl)-ethyl]-2-[4-(5-formyl-2-isopropoxy-phenoxy)-phenyl]-N-(1-phenyl-ethyl)-acetamide 
• 454185-88-7 8-hydroxy-1-[4-(2-isopropoxy-5-methoxycarbonyl-phenoxy)-benzyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 454185-97-8 {4-[5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenoxy]-phenyl}-acetic acid methyl ester 
• 454185-91-2 {4-[5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenoxy]-phenyl}-acetic acid 
• 454185-95-6 5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenol 

Relevant academic research and scientific papers

INHIBITORS OF ACETYL-COA CARBOXYLASE

The present invention relates to compounds that act as acetyl-CoA carboxylase (ACC) inhibitors. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

First enantioselective total synthesis of (-)-tejedine

(Matrix presented) The first enantioselective total synthesis of (-)-tejedine (1) is reported. Tejedine is a seco-bisbenzyltetrahydroisoquinoline isolated in 1998 as a minor component from Berberis vulgaris. The synthesis was achieved using a strategy employing four key steps, including a chiral auxiliary-assisted diastereoselective Bischler-Napieralski cyclization.