455251-67-9Relevant academic research and scientific papers
Solid phase organic synthesis of polyamine derivatives and initial biological evaluation of their antitumoral activity
Tomasi, Sophie,Le Roch, Myriam,Renault, Jacques,Corbel, Jean-Charles,Uriac, Philippe,Carboni, Bertrand,Moncoq, Damien,Martin, Benedicte,Delcros, Jean-Guy
, p. 635 - 640 (1998)
A series of N1-monosubstituted putrescine and spermine derivatives was synthesised using a solid phase methodology. We evaluated their cytotoxicity, calmodulin antagonism and polyamine uptake inhibition, pharmacological properties shared by som
