Solid phase organic synthesis of polyamine derivatives and initial biological evaluation of their antitumoral activity

Article abstract of DOI:10.1016/S0960-894X(98)00086-9

A series of N¹-monosubstituted putrescine and spermine derivatives was synthesised using a solid phase methodology. We evaluated their cytotoxicity, calmodulin antagonism and polyamine uptake inhibition, pharmacological properties shared by som