4559-92-6

Basic information

• Product Name: N-phenylmorpholine-4-carboxamide
• Synonyms: 4-morpholinecarboxamide, N-phenyl-; N-Phenylmorpholine-4-carboxamide
• CAS NO: 4559-92-6
• Molecular Formula: C₁₁H₁₄N₂O₂
• Molecular Weight: 206.2411
• Mol File: 4559-92-6.mol
• Article Data: 57

Chemical Properties

• Boiling Point: 422.8°C at 760 mmHg
• Flash Point: 209.5°C
• Density: 1.233g/cm³
• Vapor Pressure: 2.34E-07mmHg at 25°C
• Refractive Index: 1.602
• CAS DataBase Reference: N-phenylmorpholine-4-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-phenylmorpholine-4-carboxamide(4559-92-6)
• EPA Substance Registry System: N-phenylmorpholine-4-carboxamide(4559-92-6)

Safety Data

• Hazardous Substances Data: 4559-92-6(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 4910-32-1 1,3-diphenylcarbamothioate 
• 103-71-9 phenyl isocyanate 
• 102-07-8 bis(diphenyl)urea 
• 2563-97-5 2,2,2-trichloro-N-phenylacetamide 
• 201230-82-2 carbon monoxide 
• 98-95-3 nitrobenzene 
• 103-70-8 Formanilid 
• 4930-03-4 phenyl N-phenylcarbamate 
• 495-18-1 Benzohydroxamic acid 
• 2158-02-3 morpholine-4-carboxylic acid amide 
• 62-53-3 aniline 
• 100-46-9 benzylamine 
• 124-38-9 carbon dioxide 

Downstream Products

• 677326-94-2 4-(morpholinyl-4-carboxamido)benzenesulfonyl chloride 
• 105908-83-6 N-(2-chlorophenyl)morpholine-4-carboxamide 
• 52625-27-1 N-(4-chlorophenyl)morpholine-4-carboxamide 

Relevant articles and documents

Broad Scope and High-Yield Access to Unsymmetrical Acyclic [11C]Ureas for Biomedical Imaging from [11C]Carbonyl Difluoride

Effective methods are needed for labelling acyclic ureas with carbon-11 (t1/2=20.4 min) as potential radiotracers for biomedical imaging with positron emission tomography (PET). Herein, we describe the rapid and high-yield syntheses of unsymmet

Lanthanum(III) Trifluoromethanesulfonate Catalyzed Direct Synthesis of Ureas from N-Benzyloxycarbonyl-, N -Allyloxycarbonyl-, and N -2,2,2-Trichloroethoxycarbonyl-Protected Amines

A novel lanthanum triflate mediated conversion of N -benzyloxycarbonyl-, N -allyloxycarbonyl-, and N -trichloroethoxycarbonyl-protected amines into nonsymmetric ureas was discovered. In this study, lanthanum triflate was found to be an effective catalyst for preparing various nonsymmetric ureas from protected amines. A variety of protected aromatic and aliphatic carbamates reacted readily with various amines in the presence of lanthanum triflate to generate the desired ureas in high yields. This result demonstrated that this novel lanthanum triflate catalyzed preparation of ureas from Cbz, Alloc, and Troc carbamates can be employed for the formation of various urea structures.

Method for preparing asymmetric urea compound (by machine translation)

The invention provides a vehicle CO. 2 A method. for synthesizing an asymmetric urea compound by carbonylation coupling reaction of the carbonylation reagent is: and the aromatic, aliphatic primary amine compound and the aliphatic secondary amine compound and the normal pressure (100 °C, diglyme), can be efficiently prepared by using a common Lewis base and a hydrogen silane as the accelerator/CO under mild conditions. 2 The reaction produces a corresponding asymmetric urea compound. containing different functional groups, the process being operated at atmospheric pressure CO. 2 The use of an inexpensive Lewis base and, industrial silicon waste PMHS( for the green non-toxic carbonylation reagent) avoids toxic carbonylation reagents, high pressure, as an accelerator CO. 2 , The use, of the expensive dehydrating agent and the noble metal does not need to purify and separate the intermediate, and the pure product, is obtained by simple suction filtration separation after the reaction is ended . is a high efficiency, novel synthetic method . The commercial herbicide NEBURON. is successfully prepared by using the method. (by machine translation)