455957-92-3

Upstream product

• 757976-84-4 benzyl 4-(4-chloro-2-cyanophenyl)pyridine-1(4H)-carboxylate 
• 889101-57-9 4-[2-(1-(acetylamino)vinyl)-4-chlorophenyl]piperidine-1-carboxylic acid tert-butyl ester 
• 455957-91-2 tert-Butyl 4-{2-[(1S)-1-Aminoethyl]-4-Chlorophenyl]Piperidine-1-Carboxylate 
• 75-36-5 acetyl chloride 

Relevant academic research and scientific papers

Rapid identification of a scalable catalyst for the asymmetric hydrogenation of a sterically demanding aryl enamide

High throughput screening was used to find a cost-effective and scalable catalyst for the asymmetric hydrogenation of a sterically demanding enamide as an intermediate towards a new potent melanocortin receptor agonist useful in the treatment of obesity.

STEREOSELECTIVE PREPARATION OF 4-ARYL PIPERIDINE AMIDES BY ASYMMETRIC HYDROGENATION OF A PROCHIRAL ENAMIDE AND INTERMEDIATES OF THIS PROCESS

The present invention provides an efficient process for the preparation of enentiomerically enriched 4-aryl piperidine amides of structural formula (IV).

ACYLATED PIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS

Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.