889101-57-9

Upstream product

• 108-24-7 acetic anhydride 
• 732275-75-1 tert-butyl 4-(4-chloro-2-cyanophenyl)piperidine-1-carboxylate 
• 757976-84-4 benzyl 4-(4-chloro-2-cyanophenyl)pyridine-1(4H)-carboxylate 
• 917-54-4 methyllithium 

Downstream Products

• 455957-92-3 tert-butyl 4-{2-[(1S)-1-(acetylamino)ethyl]-4-chlorophenyl}piperidine-1-carboxylate 
• 1221683-35-7 C₂₀H₂₉ClN₂O₃ 

Relevant academic research and scientific papers

Rapid identification of a scalable catalyst for the asymmetric hydrogenation of a sterically demanding aryl enamide

High throughput screening was used to find a cost-effective and scalable catalyst for the asymmetric hydrogenation of a sterically demanding enamide as an intermediate towards a new potent melanocortin receptor agonist useful in the treatment of obesity.

Direct N-acetyl enamine formation: Lithium bromide mediated addition of methyllithium to nitriles

An improved protocol for N-acetyl enamine formation is disclosed which involves LiBr-mediated addition of MeLi to substituted nitriles. The resulting enamides are isolated in high yields and excellent purity which permits subsequent hydrogenation at very

STEREOSELECTIVE PREPARATION OF 4-ARYL PIPERIDINE AMIDES BY ASYMMETRIC HYDROGENATION OF A PROCHIRAL ENAMIDE AND INTERMEDIATES OF THIS PROCESS

The present invention provides an efficient process for the preparation of enentiomerically enriched 4-aryl piperidine amides of structural formula (IV).