73584-06-2

Upstream product

• 209627-01-0 [Chloro-(4-fluoro-phenyl)-trimethylsilanyl-methyl]-phosphonic acid diethyl ester 
• 456-19-9 4-fluorobenzal chloride 
• 122-52-1 triethyl phosphite 
• 63909-58-0 diethyl (4-fluorobenzyl)phosphonate 
• 21386-00-5 diethyl (4-fluorophenyl)hydroxymethylphosphonate 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 64583-17-1 1-(4-fluorophenyl)-2-(4-methylphenyl)acetylene 
• 5216-31-9 1,2-bis(4-fluorophenyl)acetylene 
• 64583-18-2 1-(para-chlorophenyl)-2-(para-fluorophenyl)acetylene 
• 64583-21-7 1-fluoro-4-(2-(4-nitrophenyl)ethynyl)benzene 
• 405-29-8 (4-fluorophenyl)phenylacetylene 
• 64583-16-0 1-fluoro-4-[2-(4-methoxyphenyl)ethynyl]benzene 
• 64583-19-3 1-bromo-4-((4-fluorophenyl)ethynyl)benzene 
• 64583-20-6 4-((4-fluorophenyl)ethynyl)benzonitrile 
• 1181811-88-0 diethyl α,α-chlorofluoro-4-fluorobenzylphosphonate 

Relevant academic research and scientific papers

Synthesis of new aryl-substituted methylphosphonic and methylenediphosphonic acids and their derivatives

Simple and versatile synthetic procedures towards new aryl-substituted hydroxymethylphosphonic and methylenediphosphonic acids via reactions of either aromatic aldehydes or their derivatives with phosphites were elaborated.

Synthesis of new functionalized aryl-substituted methylphosphonic and methylenediphosphonic acids and their derivatives

The convenient syntheses of new aryl-substituted hydroxymethylphosphonic and methylenediphosphonic acids from the aromatic aldehydes, their derivatives, and phosphorous acid esters in the presence of the effective catalysts (trimethylsilyl trifluoromethanesulfonate, zinc chloride, and cadmium iodide) were developed.

The first synthesis of diethyl α,α- chlorofluorobenzylphosphonates

Starting from a-hydroxyphosphonates, a wide variety of diethyl α,α-chlorofluorobenzylphosphonates have been obtained in pure form in a two-step procedure. The first step was chlorination of a- hydroxyphosphonates with Ph3P and CCl4,

Controlled monohalogenation of phosphonates: A new route to pure α- monohalogenated diethyl benzylphosphonates

Starting from diethyl benzylphosphonates, a wide variety of diethyl α- monofluoro, chloro, bromo and iodobenzylphosphonates have been obtained in pure form by a one-pot procedure. This high yielding method implies the intermediate protection of the benzyl anion with TMSCI followed by halogenation with an electrophilic halogenating reagent.

A highly selective synthesis of α-monofluoro- and α-monochloro- benzylphosphonates using eiectrophilic halogenation of benzylphosphonates carbanions

The selective electrophilic monofluorination and monochlorination of a wide variety of diethyl benzylphosphonates have been realized in a one-pot procedure. The monohalogenation was accomplished by intermediate of a benzylic carbanion protected with TMSCl