45815-08-5Relevant articles and documents
Dithioacetal-containing pyridopyrimidone derivative as well as preparation and application thereof
-
Paragraph 0047-0049, (2021/09/04)
The invention relates to a dithioacetal-containing pyridopyrimidone derivative as well as preparation and application thereof. The compound disclosed by the invention has a structure as shown in a formula (I) in the specification, has excellent insecticidal activity on sogatella furcifera, broad bean aphids and the like, and has a relatively good prevention and treatment effect on potato Y viruses at the same time. The compound can be used for preventing and treating hemiptera pests such as rice planthoppers and aphids, and also can be used for preventing and treating plant viruses such as potato Y viruses. The structure and the preparation process are simple, and the production cost is low.
Mesoionic pyrido[1,2-a]pyrimidinones: A novel class of insecticides inhibiting nicotinic acetylcholine receptors
Zhang, Wenming,Holyoke, Caleb W.,Barry, James,Leighty, Robert M.,Cordova, Daniel,Vincent, Daniel R.,Hughes, Kenneth A.,Tong, My-Hanh T.,McCann, Stephen F.,Xu, Ming,Briddell, Twyla A.,Pahutski, Thomas F.,Lahm, George P.
, p. 5444 - 5449 (2016/11/11)
A novel class of mesoionic pyrido[1,2-a]pyrimidinones has been discovered with exceptional insecticidal activity controlling a number of insect species, particularly hemiptera and lepidoptera. Mode-of-action studies showed that they act on nicotinic acetylcholine receptors (nAChRs) primarily as inhibitors. Here we report the discovery, evolution, and preparation of this class of chemistry. Our efforts in structure–activity relationship elucidation and biological activity evaluation are also presented.
Cationic iridium-catalyzed enantioselective activation of secondary sp 3 C-H bond adjacent to nitrogen atom
Pan, Shiguang,Matsuo, Yusuke,Endo, Kohei,Shibata, Takanori
, p. 9009 - 9015 (2012/10/30)
A cationic Ir(I)-tolBINAP complex catalyzed an enantioselective C-C bond formation, which was initiated by secondary sp3 C-H bond cleavage adjacent to nitrogen atom. A wide variety of 2-(alkylamino)pyridines and alkenes were selectively transformed into the corresponding chiral amines with moderate to almost perfect enantiomeric excesses. Alkynes were also investigated as coupling partners. The effect of alkyl structure in substrates and directing groups were studied. This transformation represents the first example of a highly enantioselective C-H bond activation of a methylene group, not at allylic or benzylic position.
A facile N-monoalkylation of aminopyridines
Tian, Zhongzhen,Li, Dongmei,Jiang, Zhaoxing,Li, Zhong
, p. 628 - 629,2 (2020/07/30)
The N-monoalkylation of 2- or 3-aminopyridines by a carboxylic acid and sodium borohydride afforded the corresponding alkylaminopyridine under mild conditions in good yields. N-Alkylaminopyridines are important intermediate for preparing N-containing heterocycles, such as flytrap aminopyridinium-based anion hosts and pharmaceuticals.
General and mild preparation of 2-aminopyridines
Londregan, Allyn T.,Jennings, Sandra,Wei, Liuqing
supporting information; experimental part, p. 5254 - 5257 (2011/02/24)
A general and facile one-pot amination procedure for the synthesis of 2-aminopyridines from the corresponding pyridine-N-oxides is presented as a mild alternative to SNAr chemistry. A variety of amines and heterocyclic-N-oxides participate effectively in this transformation which uses the phosphonium salt, PyBroP, as a means of substrate activation.
Identification of novel PPARα ligands by the structural modification of a PPARγ ligand
Usui, Shinya,Fujieda, Hiroki,Suzuki, Takayoshi,Yoshida, Naoaki,Nakagawa, Hidehiko,Miyata, Naoki
, p. 3249 - 3254 (2007/10/03)
To develop novel PPARα ligands, we designed and synthesized several 3-{3-[2-(nonylpyridin-2-ylamino)ethoxy]phenyl}propanoic acid derivatives. Compound 10, the meta isomer of a PPARγ agonist 1, has been identified as a PPARα ligand. The introduction of methyl and ethyl groups at the C-2 position of the propanoic acid of 10 further improved the PPARα-binding potency.
A convenient synthesis of 2-(alkylamino)pyridines
Krein, Douglas M.,Lowary, Todd L.
, p. 4965 - 4967 (2007/10/03)
The synthesis of a series of 2-(alkylamino) pyridines (1) in three steps from 2-aminopyridine (4) is reported. The products were obtained in 67-91% overal yield from 4.
Ruthenium complex-controlled catalytic N-mono- or N,N-dialkylation of heteroaromatic amines with alcohols
Watanabe, Yoshihisa,Morisaki, Yasuhiro,Kondo, Teruyuki,Mitsudo, Take-Aki
, p. 4214 - 4218 (2007/10/03)
Heteroaromatic amines were N-alkylated with primary alcohols at 150-200°C in the presence of a catalytic amount of various ruthenium complexes to give the corresponding monoalkylated and dialkylated amines in good to high yields. For example, 2-aminopyridine reacted with an excess of ethanol at 180°C for 20 h in the presence of dichlorotris(triphenylphosphine)ruthenium [RuCl2-(PPh3)3] to give 2-(ethylamino)pyridine (1) and 2-(diethylamino)pyridine (2) in 9% and 70% yields, respectively. On the other hand, when (η4-1,5-cyclooctadiene)(η 6-1,3,5-cyclooctatriene)ruthenium [Ru(cod)(cot)] was used as a catalyst, even in the presence of excess ethanol, 1 was obtained in 85% yield with high selectivity. The addition of tertiary phosphines and phosphites to Ru(cod)-(cot) increased the yield of the dialkylated amine.
ASYMMETRIC REDUCTION OF PROCHIRAL CYCLIC KETONES WITH LITHIUM ALUMINIUM HYDRIDE PARTIALLY DECOMPOSED BY (1R,2S)-(-)-N-METHYLEPHEDRINE AND 2-ALKYLAMINOPYRIDINE
Kawasaki, Motoji,Suzuki, Yasutaka,Terashima, Shiro
, p. 239 - 242 (2007/10/02)
The title chiral hydride was found to reduce prochiral cyclic ketones, affording the corresponding optically active cyclic alcohols in high optical (max. 98percentee) yields.
