4583-55-5

Basic information

• Product Name: 5-Bromo-2,3-dimethylindole
• Synonyms: 5-Bromo-2,3-dimethylindole;5-broMo-2,3-diMethyl-1H-indole
• CAS NO: 4583-55-5
• Molecular Formula: C₁₀H₁₀BrN
• Molecular Weight: 224.11
• Mol File: 4583-55-5.mol

Chemical Properties

• Melting Point: 136-137℃
• Boiling Point: 340.35 °C at 760 mmHg
• Flash Point: 159.638 °C
• Appearance: /
• Density: 1.487
• Refractive Index: 1.5923
• Storage Temp.: 2-8°C
• PKA: 16.91±0.30(Predicted)
• CAS DataBase Reference: 5-Bromo-2,3-dimethylindole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2,3-dimethylindole(4583-55-5)
• EPA Substance Registry System: 5-Bromo-2,3-dimethylindole(4583-55-5)

Safety Data

• Hazardous Substances Data: 4583-55-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-2,3-dimethylindole is used as a key intermediate in the synthesis of 1-[(arylsulfonyl)amino]alkylindole derivatives. These derivatives serve as dual thromboxane synthase inhibitors and thromboxane receptor antagonists, which are important in the treatment of various cardiovascular and inflammatory diseases. 5-Bromo-2,3-dimethylindole's structural features allow for the development of potent and selective therapeutic agents.
Additionally, 5-Bromo-2,3-dimethylindole is used in the preparation of modulators of secreted frizzled related protein-1 (SFRP-1). SFRP-1 is an important regulator of the Wnt signaling pathway, which plays a crucial role in cell proliferation, differentiation, and migration. Modulating SFRP-1 activity can have significant implications in the treatment of various diseases, including cancer and neurodegenerative disorders.

InChI:InChI=1S/C10H10BrN/c1-6-7(2)12-10-4-3-8(11)5-9(6)10/h3-5,12H,1-2H3

Upstream product

• 598-30-1 sec.-butyllithium 
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• 106-40-1 4-bromo-aniline 
• 78-93-3 butanone 
• 1075-34-9 5-bromo-2-methyl-1H-indole 
• 27246-81-7 3-bromophenylhydrazine hydrochloride 
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• 589-21-9 (4-bromophenyl)hydrazine 
• 1417407-56-7 1-azido-4-bromo-2-(1-ethoxy-2-methylpropan-2-yl)benzene 
• 1417408-44-6 C₁₂H₁₈BrNO 
• 1417408-30-0 4-bromo-2-(1-ethoxy-2-methylpropan-2-yl)-1-nitrobenzene 
• 1417408-14-0 2-(5-bromo-2-nitrophenyl)-2-methylpropan-1-ol 
• 1417407-98-7 methyl 2-(5-bromo-2-nitrophenyl)-2-methylpropanoate 
• 622-88-8 4-bromophenylhydrazine hydrochloride 

Downstream Products

• 29124-64-9 N-(2-acetyl-4-bromophenyl)acetamide 
• 1235481-55-6 1-(5-bromo-2,3-dimethyl-1H-indol-1-yl)-3-(phenylamino)propan-2-ol 

Relevant articles and documents

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