458550-44-2

Usage

Uses

Used in Pharmaceutical Synthesis:
N-(4-Bromophenyl)-N-(4-carbethoxyphenyl)amine is utilized as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic benefits.
Used in Antibacterial and Antifungal Applications:
In the medical field, N-(4-Bromophenyl)-N-(4-carbethoxyphenyl)amine is used as an antibacterial and antifungal agent, leveraging its inherent properties to combat infections caused by various pathogens.
Used in Treatment of Medical Conditions:
N-(4-Bromophenyl)-N-(4-carbethoxyphenyl)amine is studied for its potential role in the treatment of conditions such as diabetes and obesity, indicating its possible use as a therapeutic agent in managing these health issues.
Used in Chemical Compound and Material Development:
As a building block in the development of new chemical compounds and materials, N-(4-Bromophenyl)-N-(4-carbethoxyphenyl)amine is applied in the research and creation of innovative products across different industries, including but not limited to pharmaceuticals, agriculture, and materials science.

InChI:InChI=1/C15H14BrNO2/c1-2-19-15(18)11-3-7-13(8-4-11)17-14-9-5-12(16)6-10-14/h3-10,17H,2H2,1H3

Upstream product

• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 586-78-7 para-nitrophenyl bromide 
• 5798-75-4 Ethyl 4-bromobenzoate 
• 106-40-1 4-bromo-aniline 
• 94-09-7 p-aminoethylbenzoate 
• 111017-08-4 ethyl 4-[bis(trimethylsilyl)amino]benzoate 
• 106-37-6 1.4-dibromobenzene 
• 105230-46-4 4-carbethoxyphenyl-4-tolylazo sulfone 

Downstream Products

• 1285578-70-2 4-[(4-bromophenyl)amino]benzoic acid 

Relevant academic research and scientific papers

Evaluation of Novel N-(piperidine-4-yl)benzamide Derivatives as Potential Cell Cycle Inhibitors in HepG2 Cells

In this study, a series of novel N-(piperidine-4-yl)benzamide derivatives was designed, synthesized, and evaluated for antitumor activity. Some compounds were found to have potent antitumor activity. In particular, compound 47 showed the most potent biological activity against HepG2 cells, with an IC50 value of 0.25 μm. Western blot analysis demonstrated that compound 47 inhibited the expression of cyclin B1 and p-Rb and enhanced the expression of p21, p53, Rb, and phospho-adenosine monophosphate-activated protein kinase (p-AMPK). Further, cell cycle arrest was observed by flow cytometry (FCM). In summary, compound 47 was screened to have potential activity for the treatment of hepatocarcinoma via the induction of cell cycle arrest by a p53/p21-dependent pathway.

General preparation of primary, secondary, and tertiary aryl amines by the oxidative coupling of polyfunctional aryl and heteroaryl amidocuprates

(Chemical Equation Presented). A tolerant reaction: Functionalized tertiary amines have been prepared by the oxidative coupling of amidocuprates with chloranil used as the oxidant (see Scheme). A high tolerance of functional groups and insensitivity to steric hindrance characterize this general amination reaction.

A general animation method based on the addition of polyfunctional arylmagnesium reagents to functionalized arylazo tosylates

A one-pot reaction sequence consisting of a Grignard reaction, allylation, and reduction provides new functionalized diarylamines in good yields (see scheme, Ts = toluene-4-sulfonyl, NMP = N-methylpyrrolidine, TFA = trifluoroacetic acid). In the first ste

A new general preparation of polyfunctional diarylamines by the addition of functionalized arylmagnesium compounds to nitroarenes

The addition of functionalized arylmagnesium halides to nitroarenes in THF (-20 °C, 2 h) provides, after reductive workup (FeCl2, NaBH4), various polyfunctional diarylamines in 63-86% yield. Heterocyclic arylated amines can be prepar