437763-93-4

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 476370-97-5 1-butyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl acetate 
• 163704-72-1 4-nitro-2,6-diisopropyl aniline 
• 259225-38-2 3-amino-4-{3-[3-(benzyloxy)propoxy]phenyl}-1-butyl-1,8-naphthyridin-2(1H)-one 
• 476371-00-3 4-{3-[3-(benzyloxy)propoxy]phenyl}-1-butyl-3-nitro-1,8-naphthyridin-2(1H)-one 
• 476370-99-7 {3-[3-(benzyloxy)propoxy]phenyl}boronic acid 
• 437763-60-5 tert-butyl (4-amino-3,5-diisopropylphenyl)carbamate 
• 458558-10-6 1-[3-(benzyloxy)propoxy]-3-bromobenzene 
• 455288-51-4 4-amino-2,6-diisopropylaniline 
• 476371-02-5 tert-butyl [4-({[(4-{3-[3-(benzyloxy)propoxy]phenyl}-1-butyl-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)amino]carbonyl}amino)-3,5-diisopropylphenyl]carbamate 
• 591-20-8 3-Bromophenol 
• 139482-07-8 1-butyl-4-hydroxy-3-nitro-1,8-naphthyridin-2(1H)-one 
• 139482-08-9 1-butyl-4-chloro-3-nitro-1,8-naphthyridin-2(1H)-one 
• 74611-53-3 2-(butylamino)nicotinic acid 

Relevant academic research and scientific papers

Synthesis of SMP-797: A new potent ACAT inhibitor

A potent ACAT (acyl-CoA: cholesterol acyltransferase) inhibitor SMP-797 was effectively synthesized by the urea formation of 3-amino-4-aryl-1,8- naphthyridin-2(1H)-one and 4-amino-2,6-diisopropylamine. The synthesis of the former compound involved the Suzuki coupling reaction as a key step, and the latter was prepared by the 4-selective nitration of 2,6-diisopropylaniline using 2,3,5,6-tetrabromo-4-methyl-4-nitro-2,5-cyclohexadienone.