459-28-9

Basic information

• Product Name: 10018 2-(4-FLUORO PHENYL)-N-METHYL ETHANAMINE
• Synonyms: 10018 2-(4-FLUORO PHENYL)-N-METHYL ETHANAMINE;4-Fluoro-N-methylbenzeneethanamine;N-[2-(4-Fluorophenyl)ethyl]-N-methylamine
• CAS NO: 459-28-9
• Molecular Formula: C₉H₁₂FN
• Molecular Weight: 153.2
• Mol File: 459-28-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 10018 2-(4-FLUORO PHENYL)-N-METHYL ETHANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 10018 2-(4-FLUORO PHENYL)-N-METHYL ETHANAMINE(459-28-9)
• EPA Substance Registry System: 10018 2-(4-FLUORO PHENYL)-N-METHYL ETHANAMINE(459-28-9)

Safety Data

• Hazardous Substances Data: 459-28-9(Hazardous Substances Data)

Usage

General Description

10018 2-(4-FLUORO PHENYL)-N-METHYL ETHANAMINE is a chemical compound that belongs to the class of organic compounds known as fluorobenzenes. The molecule contains an aromatic ring, specifically, a benzene, substituted by a fluorine atom and connected to an ethanamine via a two carbon spacer. In its structure, it also features an amine group, which is modified by a methyl group. This chemical has not been widely studied; hence, properties such as its boiling point, melting point and toxicity are not well documented. Its potential applications could be in the fields of chemical research, organic synthesis or potentially as a pharmaceutical intermediate, but further research is needed.

Upstream product

• 332-42-3 (2-bromoethyl)-4-fluorobenzene 
• 74-89-5 methylamine 
• 864960-86-1 C₁₆H₁₈FN 
• 332-43-4 1-(2-chloroethyl)-4-fluorobenzene 
• 1583-88-6 4-fluoro-2-phenethylamine 
• 864960-85-0 C₁₆H₁₆FNO 
• 405-50-5 p-Fluorophenylacetic acid 
• 459-04-1 4-Fluorophenylacetyl chloride 
• 152859-42-2 2-(4-fluorophenyl)-N-methylacetamide 
• 352-13-6 4-flourophenylmagnesium bromide 
• 7589-27-7 2-(4-Fluorophenyl)ethanol 
• 581-96-4 2-naphthylacetic acid 
• 86-87-3 naphth-1-yl acetic acid 
• 104-03-0 4-nitrobenzeneacetic acid 

Downstream Products

• 864961-12-6 7-oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonic acid [2-(4-fluorophenyl)-ethyl]-methyl-amide 
• 864961-99-9 5-bromo-thiophene-3-carboxylic acid [2-(4-fluorophenyl)-ethyl]-amide 
• 1135433-88-3 C₁₃H₁₄ClFN₄ 
• 864961-13-7 7-Oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonic acid [2-(4-fluoro-2-nitro-phenyl)-ethyl]-methyl-amide 
• 864961-14-8 7-Oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonic acid [2-(4-fluoro-3-nitro-Phenyl)-ethyl]-methyl-amide 
• 1267494-70-1 2-cyano-N-(4-fluorophenethyl)-N-methylacetamide 
• 1431791-44-4 2-cyano-2-diazo-N-(4-fluorophenethyl)-N-methylacetamide 

Relevant articles and documents

Iron-Catalyzed Intramolecular C—H Amidation of N-Benzoyloxyureas

A redox-neutral Fe-catalyzed intramolecular C—H amidation of N-benzoyloxyureas is described. This methodology employs a simple iron complex in situ generated from Fe(OTf)2 and bipyridine as the catalyst and N-benzoyloxyureas as the nitrene prec

α-Diazo-β-ketonitriles: Uniquely reactive substrates for arene and alkene cyclopropanation

An investigation of the intramolecular cyclopropanation reactions of α-diazo-β-ketonitriles is reported. These studies reveal that α-diazo-β-ketonitriles exhibit unique reactivity in their ability to undergo arene cyclopropanation reactions; other similar acceptor-acceptor- substituted diazo substrates instead produce mixtures of C-H insertion and dimerization products. α-Diazo-β-ketonitriles also undergo highly efficient intramolecular cyclopropanation of tri- and tetrasubstituted alkenes. In addition, the α-cyano-α-ketocyclopropane products are demonstrated to serve as substrates for SN2, SN2′, and aldehyde cycloaddition reactions.

Structure-activity correlations for β-phenethylamines at human trace amine receptor 1

A cell line in which RD-HGA16 cells were stably transfected with the hTAAR 1 receptor was created and utilized to carry out a systematic evaluation of a series of β-phenethylamines. Fair agreement was observed with data obtained for aryl and ethylene chain substituted analogs in an AV12-664 cell line in which hemagglutinin-tagged hTAAR 1 was stably co-expressed with rat Gαs. Analogs with multiple substituents as well as analogs with bulky groups were found to be partial agonists. Analogs in which the primary amino group was converted to a secondary or a tertiary amino group by N-methylation were also partial agonists. Comparative Molecular Field Analysis (CoMFA) using the potency data yielded a regression coefficient r2 of 0.824. The steric field contribution to the model was 61% with the balance (39%) contributed by the electrostatic field. The collective results suggest that increasing steric bulk both at the amino nitrogen, particularly by N-dimethylation, and at the 4-position of the aromatic ring leads to low efficacy ligands.