4595-96-4

Basic information

• Product Name: N-(thiophen-2-ylMethyl)benzaMide
• Synonyms: N-(thiophen-2-ylMethyl)benzaMide
• CAS NO: 4595-96-4
• Molecular Formula: C₁₂H₁₁NOS
• Molecular Weight: 217.28684
• Mol File: 4595-96-4.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 437.8°C at 760 mmHg
• Flash Point: 218.6°C
• Appearance: /
• Density: 1.207g/cm³
• Vapor Pressure: 7.26E-08mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-(thiophen-2-ylMethyl)benzaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(thiophen-2-ylMethyl)benzaMide(4595-96-4)
• EPA Substance Registry System: N-(thiophen-2-ylMethyl)benzaMide(4595-96-4)

Safety Data

• Hazardous Substances Data: 4595-96-4(Hazardous Substances Data)

Usage

General Description

N-(thiophen-2-ylmethyl)benzamide is a chemical compound consisting of a benzene ring attached to a thiophene ring and a carboxamide functional group. It belongs to the class of organic compounds known as benzamides. Benzamides are compounds that contain a benzene ring linked to an amide group. N-(thiophen-2-ylmethyl)benzamide may have potential applications in the field of organic synthesis and pharmaceuticals due to its unique structure and properties. Thiophenes are often found in pharmaceutical drugs and biologically active compounds, suggesting that N-(thiophen-2-ylmethyl)benzamide may also have biological and pharmacological activities worth exploring. Additionally, its benzamide moiety can be a key structural feature in drug discovery and development.

InChI:InChI=1/C12H11NOS/c14-12(10-5-2-1-3-6-10)13-9-11-7-4-8-15-11/h1-8H,9H2,(H,13,14)

Upstream product

• 27757-85-3 2-Aminomethylthiophene 
• 98-88-4 benzoyl chloride 
• 100-47-0 benzonitrile 
• 636-72-6 2-thiophenemethanol 
• 55-21-0 benzamide 
• 94-36-0 dibenzoyl peroxide 
• 100-51-6 benzyl alcohol 
• 7338-94-5 1,3-diphenyl-2-propynone 
• 75815-41-7 N-(thien-2-ylmethyl)phthalimide 
• 85-44-9 phthalic anhydride 
• 591-50-4 iodobenzene 
• 93-58-3 benzoic acid methyl ester 
• 769-78-8 vinyl benzoate 
• 98-03-3 thiophene-2-carbaldehyde 

Downstream Products

• 428817-03-2 N-(2-azido-benzoyl)-N-thiophen-2-ylmethyl-benzamide 
• 73325-61-8 N-benzyl-1-(thiophen-2-yl)methanamine 
• 101561-61-9 N-benzylidene-1-(thiophen-2-yl)methanamine 

Relevant articles and documents

Zirconium Oxide-Catalyzed Direct Amidation of Unactivated Esters under Continuous-Flow Conditions

A sustainable and environmentally benign direct amidation reaction of unactivated esters with amines has been developed in a continuous-flow system. A commercially available amorphous zirconium oxide was found to be an efficient catalyst for this reaction. While the typical amidation of esters with amines requires a stoichiometric amount of a promoter or metal activator, the present continuous-flow method enabled the direct amidation reaction under additive-free conditions with an extensive diversity towards various functional groups. High yields of the products were obtained with a nearly equimolar proportion of starting materials to reduce byproduct formation, which renders this process applicable for use in a sequential-flow system. (Figure presented.).

An unprecedented cobalt-catalyzed selective aroylation of primary amines with aroyl peroxides

A novel and facile cobalt-catalyzed selective aroylation of primary amines with aroyl peroxides was developed for the synthesis of aryl amides. It was unprecedented that C[sbnd]N bond formation product was selectively generated without the common N[sbnd]O bond formation product. Aroyl peroxides act as the sole aroylation reagent without additional base or oxidant. The reactions proceeded under mild conditions and showed broad substrates scope with a series of primary amines and aroyl peroxides.

An open-source approach to automation in organic synthesis: The flow chemical formation of benzamides using an inline liquid-liquid extraction system and a homemade 3-axis autosampling/product-collection device

Several open-source hardware and software technologies (RAMPS, Python, PySerial, OpenCV) were used to control an automated flow chemical synthesis system. The system was used to effect the synthesis of a series of benzamides. An inexpensive Raspberry Pi single board computer provided an electronic interface between the control computer and the RAMPS motor driver boards.