460313-68-2Relevant academic research and scientific papers
A flexible strategy for the divergent modification of pleuromutilin
Bacque, Eric,Pautrat, Francois,Zard, Samir Z.
, p. 2312 - 2313 (2002)
The complex antibacterial natural product, pleuromutilin, can be directly modified by the radical addition reaction of various xanthates to the unactivated terminal olefin present on C-12.
A radical exchange process: Synthesis of bicyclo[1.1.1]pentane derivatives of xanthates
Rout, Saroj Kumar,Marghem, Gilles,Lan, Junjie,Leyssens, Tom,Riant, Olivier
supporting information, p. 14976 - 14979 (2019/12/24)
Bicyclo[1.1.1]pentane (BCP) replacement as a bioisostere in drug molecules has an influence on their permeability, aqueous solubility and in vitro metabolic stability. Thus, the chemical installation of the BCP unit into a chemical entity remains a significant challenge from a synthetic point of view. Here, we have presented a new approach for the installation of the BCP unit on the xanthate moiety by means of a radical exchange process.
The direct catalytic enantioselective synthesis of protected aryl β-hydroxy-α-amino acids
Willis, Michael C.,Cutting, Gary A.,Piccio, Vincent J.-D.,Durbin, Matthew J.,John, Matthew P.
, p. 1543 - 1545 (2007/10/03)
The combination of three reagents-a tridentate pybox ligand (pybox = pyridine bis(oxazoline)), magnesium perchlorate, and Huenig base (iPr 2EtN)-allows the catalytic generation of a chiral glycine enolate from 1 that undergoes highly enantiosel
Lewis acid-promoted synthesis and reactivity of β-O-benzylhydroxylamino imides derived from D-glyceraldehyde
Cardillo, Giuliana,Gentilucci, Luca,de Matteis, Valeria
, p. 5957 - 5962 (2007/10/03)
This paper describes the synthesis and use β-hydroxylamino imides derived from D-glyceraldehyde possessing a number of reactive sites that operate synergistically or alternatively to bring about highly regio- and diastereoselective transformations to give an optically pure aziridine-2-imide, a dihydro pyrimidine-2,4-dione, or a lactone. Both the syntheses, via the diastereoselective 1,4-conjugate addition of O-benzyl hydroxylamine to α,β-unsaturated imides, and transformations can be simply tuned by choosing between different Lewis acids.
