462123-55-3Relevant academic research and scientific papers
Synthesis of thioridazine-VLA-4 antagonist hybrids using N-propargyl northioridazine enantiomers
Martyn,Willis,Kelso
, p. 2796 - 2809 (2020)
Herein, we report the synthesis of thioridazine-VLA-4 hybrid epimers. These hybrid molecules were obtained by means of a click reaction involving N-propargyl northioridazine enantiomers and an azide containing VLA-4 antagonist. A synthesis of northioridaz
AZA-BRIDGED-BICYCLIC AMINO ACID DERIVATIVES AS ALPHA 4 INTEGRIN ANTAGONISTS
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Page/Page column 49-50, (2010/11/23)
The invention is directed to aza-bridged-bicyclic compounds of Formula (I) and pharmaceutically acceptable salts thereof. The compounds are useful α4 integrin receptor antagonists and, in particular, α4β1 and α4β7 integrin receptor antagonists. The invent
Aza-bicyclic amino acid carboxamides as α4β 1/α4β7 integrin receptor antagonists
Dyatkin, Alexey B.,Gong, Yong,Miskowski, Tamara A.,Kimball, Edward S.,Prouty, Stephen M.,Fisher, M. Carolyn,Santulli, Rosemary J.,Schneider, Craig R.,Wallace, Nathaniel H.,Hornby, Pamela J.,Diamond, Craig,Kinney, William A.,Maryanoff, Bruce E.,Damiano, Bruce P.,He, Wei
, p. 6693 - 6702 (2007/10/03)
A series of N-carboxy, N-alkyl, and N-carboxamido azabicyclo[2.2.2]octane carboxamides were prepared and assayed for inhibition of α 4β1-VCAM-1 and α4β7- MAdCAM-1 interactions. Potency and α4β1/
Phenylalanine derivatives
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Page column 19, (2010/01/30)
Phenylalanine derivatives of formula (1) are described: in which:Ar1 is an aromatic or heteroaromatic group;L1 is a linker atom or group;R is a carboxylic acid or a derivative thereof;Ar2 is an optionally substituted aromatic or heteroaromatic group;and the salts, solvates, hydrates and N-oxides thereof.The compounds are able to inhibit the binding of à4 integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.
