46231-41-8

Usage

Use

Preservative in cosmetics and personal care products

+ Antimicrobial properties

Prevents growth of bacteria and fungi
+ Extends shelf life of products

Use in pharmaceutical products

+ Preservative and antiseptic properties

Potential concerns

+ Toxicity
+ Irritant effects, especially on sensitive skin

Regulation

Use is regulated in some countries

Recommendation

Use products containing 2-(2-phenoxyethyl)guanidine with caution.

Upstream product

• 4023-02-3 1H-pyrazole-1-carboximidamide hydrochloride 
• 1758-46-9 2-phenoxyethanamine 
• 14527-26-5 2-methylisothiourea sulphate 
• 107-14-2 chloroacetonitrile 
• 108-95-2 phenol 

Relevant academic research and scientific papers

Solid-phase synthesis of N,N' substituted guanidines

An efficient method for the solid-phase synthesis of substituted guanidines is presented. A variety of alcohols react with resin-bound N, N'- bis(t-butoxycarbonyl)thiopseudourea under Mitsunobu conditions to give the corresponding alkylated thiopseudoureas. The guanidines are liberated from the resin upon exposure to ammonia or primary amines.

REMOVAL OF SENESCENCE-ASSOCIATED MACROPHAGES

In various aspects and embodiments provided are compounds, compositions and methods relating to aging, senescent cells (SCs) and/or senescence associate macrophages (SAMs). In certain aspects and embodiments provided are compounds and compositions that selectively kill or reprogram senescent cells (SCs) and or senescence associate macrophages (SAMs) and associated methods. In some embodiments, the compounds compositions and methods treat or reverse aging and/or age-related diseases.