464170-02-3Relevant articles and documents
Asymmetric synthesis of a selective endothelin A receptor antagonist
Kato, Yoshiaki,Niiyama, Kenji,Nemoto, Takayuki,Jona, Hideki,Akao, Atsushi,Okada, Shigemitsu,Song, Zhiguo J,Zhao, Matthew,Tsuchiya, Yoshimi,Tomimoto, Koji,Mase, Toshiaki
, p. 3409 - 3415 (2002)
An asymmetric synthesis of a selective endothelin A receptor antagonist 1b is described. A highly substituted pyridine intermediate 11a was efficiently prepared via a mono-amination of inexpensive 2,6-dichloropyridine followed by a Vilsmeier formylation.