464170-11-4

Upstream product

• 464170-09-0 tert-butyl (3S)-3-{6-(N-benzyl-N-isopropylamino)-2-[4-methoxy-2-(4-methoxy-benzyloxymethyl)benzoyl]-3-pyridinyl}-3-(2,3-dihydro-1-benzofuran-6-yl)propanoate 
• 464170-07-8 tert-butyl (3S)-3-[6-(N-benzyl-N-isopropylamino)-2-butoxycarbonyl-3-pyridinyl]-3-(2,3-dihydro-1-benzofuran-6-yl)propanoate 
• 464170-06-7 tert-butyl (3S)-3-[6-(N-benzyl-N-isopropylamino)-2-chloro-3-pyridinyl]-3-(2,3-dihydro-1-benzofuran-6-yl)propanoate 
• 464170-04-5 2-(N-benzylisopropylamino)-6-chloro-5-{(E)-[2-(4S,5S)-4-methoxymethyl-5-(4-methylthiophenyl)-4,5-dihydro-1,3-oxazol-2-yl]vinyl}pyridine 
• 464170-05-6 (3S)-3-[6-(N-benzyl-N-isopropylamino)-2-chloro-3-pyridinyl]-3-(2,3-dihydro-1-benzofuran-6-yl)propanoic acid 
• 464170-03-4 2-(N-benzylisopropylamino)-6-chloro-5-formylpyridine 
• 464170-02-3 2-(N-benzylisopropylamino)-6-chloropyridine 
• 102-97-6 Benzyl-isopropyl-amin 
• 2402-78-0 2,6-dichloropyridine 
• 464170-10-3 tert-butyl (3S)-3-{6-(N-benzyl-N-isopropylamino)-2-(S)-hydroxy[4-methoxy-2-(4-methoxybenzyloxymethyl)phenyl]-methyl-3-pyridinyl}-3-(2,3-dihydro-1-benzofuran-6-yl)propanoate 

Downstream Products

• 494841-92-8 tert-butyl (5S,6R,7R)-(+)-5-(2,3-dihydrobenzo[b]furan-6-yl)-7-(2-hydroxymethyl-4-methoxyphenyl)-2-(N-isopropylamino)-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylate 

Relevant academic research and scientific papers

Asymmetric synthesis of a selective endothelin A receptor antagonist

An asymmetric synthesis of a selective endothelin A receptor antagonist 1b is described. A highly substituted pyridine intermediate 11a was efficiently prepared via a mono-amination of inexpensive 2,6-dichloropyridine followed by a Vilsmeier formylation.