4645-02-7

Basic information

• Product Name: 2,4-dihydro-4-[(2-methoxyphenyl)azo]-5-methyl-2-phenyl-3H-pyrazol-3-one
• CAS NO: 4645-02-7
• Molecular Formula: C17H16N4O2
• Molecular Weight: 308.33454
• EINECS: 225-074-3
• Mol File: 4645-02-7.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,4-dihydro-4-[(2-methoxyphenyl)azo]-5-methyl-2-phenyl-3H-pyrazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dihydro-4-[(2-methoxyphenyl)azo]-5-methyl-2-phenyl-3H-pyrazol-3-one(4645-02-7)
• EPA Substance Registry System: 2,4-dihydro-4-[(2-methoxyphenyl)azo]-5-methyl-2-phenyl-3H-pyrazol-3-one(4645-02-7)

Safety Data

• Hazardous Substances Data: 4645-02-7(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 1463-10-1 5-Methyluridine 
• 116165-26-5 5-Methyl-1-trimethylsilanyl-1H-pyrimidine-2,4-dione 
• 13035-61-5 1,2,3,5-tetraacetylribose 
• 65-71-4 thymin 
• 61849-90-9 1,2,3,5-tetra-O-acetylcarba-α-D-lyxofuranose 
• 127761-87-9 (3R,4R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-2,6-dioxa-bicyclo[3.1.0]hexan-4-ol 
• 7288-28-0 2,4-bis(trimethylsiloxy)-5-methylpyrimidine 
• 127761-84-6 (1R,3R,4R,5S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-4-trimethylsilanyloxy-2,6-dioxa-bicyclo[3.1.0]hexane 
• 127791-68-8 1,4-anhydro-5-O-(tert-butyldiphenylsilyl)-2-deoxy-3-O-(trimethylsilyl)-D-erythro-pent-1-enitol 
• 61826-42-4 tetra-O-acetyl-D-arabinofuranose 
• 4348-74-7 1-(α-D-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione 
• 605-23-2 thymine arabinoside 
• 64609-15-0 2,3,5-tri-O-acetyl-D-xylofuranose 

Downstream Products

• 143485-05-6 7'-O-(4,4'-dimethoxytrityl)-5-methylmorpholino uridine 
• 1037305-43-3 6'-O-(4,4'-dimethoxytrityl)-3'-O-cyanoethyl-1'-(N¹-thymidine) morpholino (N,N-diisopropylamino) phosphorodiamidite 
• 138239-62-0 1-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 
• 4348-62-3 1-(α-D-Lyxofuranosyl)-thymin 

Relevant articles and documents

Transglycosylation in the Modification and Isotope Labeling of Pyrimidine Nucleosides

Transglycosylation of pyrimidine nucleosides is demonstrated in a one-pot synthesis of uridine derivatives under microwave irradiation. Inductive activation of 2′,3′,5′-tri-O-acetyl uridine with a 5-nitro group produces a more-reactive glycosyl donor. Under optimized Vorbrüggen conditions, the 5-nitrouridine facilitates a reversible nucleobase exchange with a series of 5-substituted uracils. The protocol is also exemplified in a gram-scale reaction under thermal heating. The strategy provides easy access to isotopically labeled uridine.

Modified nucleosides for the treatment of viral infections and abnormal cellular proliferation

The disclosed invention is a composition for and a method of seating a Flaviviridae (including BVDV and HCV), Orthomyxoviridae (including Influenza A and B) or Paramyxoviridae (including RSV) infection, or conditions related to abnormal cellular proliferation, in a host, including animals, and especially humans, using a nucleoside of general formula (I)-(XXIII) or its pharmaceutically acceptable salt or prodrug. This invention also provides an effective process to quantify the viral load, and in particular BVDV, HCV or West Nile Virus load, in a host, using real-time polymerase chain reaction (“RT-PCR”). Additionally, the invention discloses probe molecules that can fluoresce proportionally to the amount of virus present in a sample.

Effective synthesis of nucleosides utilizing O-acetyl-glycosyl chlorides as glycosyl donors in the absence of catalyst: Mechanism revision and application to silyl-hilbert-johnson reaction

An effective synthesis of nucleosides using glycosyl chlorides as glycosyl donors in the absence of Lewis acid has been developed. Glycosyl chlorides have been shown to be pivotal intermediates in the classical silyl-Hilbert-Johnson reaction. A possible mechanism that differs from the currently accepted mechanism advanced by Vorbrueggen has been proposed and verified by experiments. In practice, this catalyst-free method provides easy access to Capecitabine in high yield.