127791-68-8

Upstream product

• 101527-40-6 5'-O-tert-butyldiphenylsilylthymidine 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 10416-59-8 N,O-bis-(trimethylsilyl)-acetamide 
• 50-89-5 thymidine 

Downstream Products

• 127761-84-6 (1R,3R,4R,5S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-4-trimethylsilanyloxy-2,6-dioxa-bicyclo[3.1.0]hexane 
• 401813-15-8 (2S,3S)-2-(tert-butyldiphenylsilanyloxymethyl)tetrahydrofuran-3-ol 
• 91547-59-0 (2R,3S)-2-(hydroxymethyl)tetrahydrofuran-3-ol 
• 95049-01-7 5-O-(4,4'-dimethoxytriphenylmethyl)-1,4-anhydro-2-deoxy-D-ribitol 
• 4348-74-7 1-(α-D-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione 
• 127761-89-1 1-(2,3,5-tri-O-acetyl-α-D-arabinofuranosyl)thymine 
• 127761-86-8 1-(3'-(trimethylsilyl)-5'-(tert-butyldiphenylsilyl)-α-D-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione 
• 127761-83-5 1,4-anhydro-5-O-(tert-butyldiphenylsilyl)-2-deoxy-D-erythro-pent-1-enitol 

Relevant academic research and scientific papers

Organocatalytic Conversion of Nucleosides to Furanoid Glycals

A class of organocatalysts that are highly active for the conversion of 2′-deoxynucleosides to furanoid glycals have been discovered. These phosphorimides, (Ph2PS)2NH and (Ph2PSe)2NH, were shown to effectively mediate persilylation of 2′-deoxynucleosides

Practical and Reliable Synthesis of 1,2-Dideoxy-D-ribofuranose and its Application in RNAi Studies

We developed a practical and reliable method for synthesizing an abasic deoxyribonucleoside, 1,2-dideoxy-D-ribofuranose (dRH) via elimination of nucleobase from thymidine. To synthesize oligonucleotides bearing dRH by the standard ph

One-pot synthesis of β-N-glycosyl imidazole analogues via a palladium-catalysed decarboxylative allylation

A concise and highly efficient strategy for the synthesis of N-glycosyl imidazole analogues is reported. This reaction is based on a palladium catalysed decarboxylative allylation and three steps, namely, carbamation, decarboxylation and allylation are involved. All the substrates can afford the desired products with excellent yields and selectivities. the Partner Organisations 2014.

A new and easy synthesis of silylated furanoid glycals in one step from nucleotides

Silylated furanoid glycals are synthesized in high yields by elimination of the nucleobase in thymidine (1a) and 5'-O-(tert-butyldiphenylsilyl)thymidine (1b) on treatment with 1,1,1,3,3,3-hexamethyldisilazane (HMDS) in the presence of ammonium sulfate at