464892-44-2

Usage

General Description

The chemical "1H-Imidazole-2-carboxylicacid,1-methyl-4-[[(1-methyl-1H-imidazol-2-yl)thio]acetyl]-, hydrochloride (1:1)" is a compound with the molecular formula C11H14N4O2S.HCl. It is a derivative of imidazole with a thioacetyl group and a methyl group attached. 1H-Imidazole-2-carboxylicacid,1-methyl-4-[[(1-methyl-1H-imidazol-2- has potential pharmaceutical applications due to its imidazole ring, which is a common structural motif in pharmaceutical compounds. It is used in the synthesis of various drugs, such as antifungal agents, antihistamines, and other pharmaceuticals. The hydrochloride form of the compound enhances its solubility and stability, making it easier to handle and formulate for pharmaceutical use. Overall, this chemical has significant potential for use in the pharmaceutical industry.

Upstream product

• 849665-11-8 methyl 4-(N-methyl-1H-imidazole-2-carboxamido)-N-methyl-1H-imidazole-2-carboxylate 
• 162085-97-4 methyl 4-amino-1-methyl-1H-imidazole-2-carboxylate 
• 30148-23-3 2-trichloroacetyl-1-methylimidazole 
• 1238707-21-5 tert-butyl 4-(1-methylimidazole-2-carboxamido)-1-methylimidazole-2-carboxylate 
• 500701-36-0 methyl 4-[(tert-butoxycarbonyl)amino]-N-methyl-1H-imidazole-2-carboxylate 

Relevant academic research and scientific papers

Facile dimer synthesis for DNA-binding polyamide ligands

(Equation Presented). Pyrrole-imidazole polyamide ligands are highly sequence specific synthetic DNA-binding ligands that bind with high affinity. To counter the synthetic difficulties associated with coupling the electron-rich heterocyclic acids to the electron-deficient nucleophilic imidazole amine, a novel approach is described for synthesis of Fmoc-protected dimers for solid-phase peptide synthesis (SPPS). This method produces the dimers in high yields, is broadly applicable to other heterocyclic-containing polyamides, and results in improved ligand yields and synthesis times.

Synthesis of DNA-sequence-selective hairpin polyamide platinum complexes

Two DNA-sequence-selective hairpin polyamide platinum(II) complexes, containing pyrrole and imidazole heterocyclic rings, have been synthesised by different methods. A six-ring complex, selective for (A/T)GGG-(A/T) DNA sequences, was made by using solid-phase synthesis, whilst an eight-ring complex, selective for (A/ T)CCTG(A/T) DNA sequences, was made by utilising standard wet chemistry. Solid-phase synthesis resulted in a significantly higher yield, required less purification and is more efficient than the wet synthesis; as such, it is the preferred method for further work. The metal complexes were characterised by 1H and 195Pt NMR spectroscopy and ESI mass spectrometry. The two compounds provide a foundation for the synthesis of more complex molecules containing multiple hairpins and/or platinum groups.

OLIGOHETEROAROMATIC LUMINISCENT ASSEMBLIES AS HIGH-AFFINITY DNA SEQUENCE-DIRECTED LIGANDS

The present invention provides a novel class of oligoheteroaromatic assemblies with luminescence characteristics and composition based on integrated polyheterocyclic polyamide oligomers of multiple nitrogen-containing heteroaromatic of the general formula (I) This novel class of compounds of the present invention is capable of binding to targeted DNA sequence in the minor groove, and thus is useful for genomics applications. In particular, the compounds of the invention binds to the DNA at a binding stoichiometry of 2: 1 ternary complexation with very high affinity and sequence selectivity.