46698-36-6

Usage

Uses

Used in Pharmaceutical Synthesis:
4-Chloro-3'-fluorobenzophenone is used as an intermediate in the synthesis of various pharmaceuticals. Its chloro and fluoro substituents facilitate a range of organic reactions, contributing to the development of new medicinal compounds.
Used in Polymer Production:
In the polymer industry, 4-Chloro-3'-fluorobenzophenone serves as a photoinitiator. It plays a crucial role in the curing process of certain polymers, enabling the formation of solid materials through exposure to light.
Used in Cosmetics:
4-Chloro-3'-fluorobenzophenone is utilized as a UV filter in cosmetic products, such as sunscreens. Its ability to absorb ultraviolet radiation helps protect the skin from harmful UV rays, reducing the risk of sunburn and skin damage.
Safety Note:
Given its classification as a hazardous substance, 4-Chloro-3'-fluorobenzophenone should be handled with care, adhering to proper safety protocols to minimize health and environmental risks.

InChI:InChI=1/C13H8ClFO/c14-11-6-4-9(5-7-11)13(16)10-2-1-3-12(15)8-10/h1-8H

Upstream product

• 108-90-7 chlorobenzene 
• 1711-07-5 3-fluorobenzoyl chloride 
• 637-87-6 1-Chloro-4-iodobenzene 
• 201230-82-2 carbon monoxide 
• 67-66-3 chloroform 

Downstream Products

• 93765-43-6 (4-chlorophenyl)(3-fluorophenyl)pyrimidin-5-yl methanol 

Relevant academic research and scientific papers

Iron-catalyzed carbonylation of aryl halides with arylborons using stoichiometric chloroform as the carbon monoxide source

A general iron-catalyzed carbonylative Suzuki-Miyaura coupling of aryl halides with arylborons is reported, using stoichiometric CHCl3 as the CO source. The high efficiency, economy, selectivity, and operational simplicity of this transformation make this method a valuable tool in organic synthesis. Importantly, the presented strategy allows effective 13C labeling simply by using the commercially available 13C-labeled CHCl3. On the basis of the initial mechanistic exploration, an aryl radical intermediate is proposed in the present carbonylation process.

Transition-metal-free, ambient-pressure carbonylative cross-coupling reactions of aryl halides with potassium aryltrifluoroborates

We disclose an unprecedented transition-metal-free carbonylative cross coupling of aryl halides with potassium aryl trifluoroborates even at atmospheric pressure of carbon monoxide. This protocol is efficient, operationally simple, and shows wide scope with regard to both aryl halides and potassium aryl trifluoroborates containing a series of active functional groups.

Analogues of fenarimol are potent inhibitors of trypanosoma cruzi and are efficacious in a murine model of chagas disease

We report the discovery of nontoxic fungicide fenarimol (1) as an inhibitor of Trypanosoma cruzi (T. cruzi), the causative agent of Chagas disease, and the results of structure-activity investigations leading to potent analogues with low nM IC50s in a T. cruzi whole cell in vitro assay. Lead compounds suppressed blood parasitemia to virtually undetectable levels after once daily oral dosing in mouse models of T. cruzi infection. Compounds are chemically tractable, allowing rapid optimization of target biological activity and drug characteristics. Chemical and biological studies undertaken in the development of the fenarimol series toward the goal of delivering a new drug candidate for Chagas disease are reported.