46739-62-2Relevant academic research and scientific papers
Construction of α-Amino Azines via Thianthrenation-Enabled Photocatalyzed Hydroarylation of Azine-Substituted Enamides with Arenes
Zhang, Yu-Lan,Wang, Gang-Hu,Wu, Yichen,Zhu, Chun-Yin,Wang, Peng
, p. 8522 - 8526 (2021/11/13)
α-Amino azines are widely found in pharmaceuticals and ligands. Herein, we report a practical method for accessing this class of compounds via photocatalyzed hydroarylation of azine-substituted enamides with the in situ-generated aryl thianthrenium salts as the radical precursor. This reaction features a broad substrate scope, good functional group tolerance, and mild conditions and is suitable for the late-stage installation of α-amino azines in complex structures.
An efficient synthesis of 2-alkylpyridines using an alkylation/double decarboxylation strategy
Donald, Craig,Boyd, Scott
supporting information; experimental part, p. 3853 - 3856 (2012/08/13)
We have discovered a novel route for synthesising 2-alkylpyridines by exploiting the decarboxylation of pyridyl malonate esters. Herein we report the synthesis of a number of examples and describe how the reaction was discovered.
Catalytic alkylation of methyl-N-heteroaromatics with alcohols
Blank, Benoit,Kempe, Rhett
supporting information; experimental part, p. 924 - 925 (2010/03/31)
(Chemical Equation Presented) A novel catalytic C-C coupling reaction in which N-heteroaromatic-substituted methyl groups are efficiently alkylated using primary alcohols is introduced. The synthesis protocol is based on iridium catalysts and most likely relies on the borrowing hydrogen or hydrogen autotransfer mechanism. A variety of substrate combinations can readily be employed in this reaction, including pyrimidines, pyrazines, pyridazines, and even fairly activated 2- and 4-picolines. Copyright
New studies of Rh-catalyzed addition of boronic acids under basic conditions in aqueous medium
Amengual, Rémi,Michelet, Véronique,Genêt, Jean-Pierre
, p. 5905 - 5908 (2007/10/03)
Rh-catalyzed C-C bond formation in neat water under basic conditions has been efficiently performed. The addition of various boronic acids to styrene, 2-vinylpyridine, and cyclic α,β-unsaturated ketones has been realized with high selectivity and yield. We have shown that m-TPPTC (tris(m-carboxyphenyl)phosphane trilithium salt) exhibited a higher reactivity compared to TPPTS. These couplings could also be conducted very efficiently under basic and phosphaneless conditions to give functionalized aryl derivatives. The benefits of the additional anionic ligand m-TPPTC lied in the successful recycling experiments of 1,4-addition of phenylboronic acid to cyclohexenone, with no loss of the water-soluble catalyst.
