4676-99-7

Basic information

• Product Name: 3H-Indol-3-one, 2-phenyl-, oxime
• CAS NO: 4676-99-7
• Molecular Formula: C14H10N2O
• Molecular Weight: 222.246
• Mol File: 4676-99-7.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 3H-Indol-3-one, 2-phenyl-, oxime(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-Indol-3-one, 2-phenyl-, oxime(4676-99-7)
• EPA Substance Registry System: 3H-Indol-3-one, 2-phenyl-, oxime(4676-99-7)

Safety Data

• Hazardous Substances Data: 4676-99-7(Hazardous Substances Data)

Upstream product

• 948-65-2 2-phenyl-indole 
• 110-46-3 isopentyl nitrite 
• 2989-63-1 2-phenyl-3H-indol-3-one 
• 64-17-5 ethanol 
• 31917-92-7 1-oxy-2-phenyl-indol-3-one oxime 
• 64109-88-2 2-phenyl-3-H-indole 
• 7803-49-8 hydroxylamine 
• 302-01-2 hydrazine 
• 64-19-7 acetic acid 
• 1969-74-0 2-phenylisatogen 
• 67-64-1 acetone 
• 583-11-9 N-(1-phenylethylidene)phenylhydrazine 
• 5883-81-8 2-anilinoacetophenone 
• 62-53-3 aniline 

Downstream Products

• 106367-37-7 3-<(1-Oxyl-2,2,5,5-tetramethyl-2,5-dihydropyrrole-3-carbonyloxy)-imino>-2-phenyl-3H-indole 
• 40288-69-5 N-(2-cyanophenyl)benzamide 
• 23041-45-4 3-amino-2-phenylindole 
• 1022-45-3 2-phenyl-4(3H)-quinazolinone 
• 4771-06-6 2-phenyl-3-nitro-1H-indole 
• 579-93-1 2-(Benzoylamino)benzoic Acid 
• 2989-63-1 2-phenyl-3H-indol-3-one 
• 6339-33-9 3-imino-2-phenyl-3H-indole 
• 1060712-42-6 (E)-2-phenyl-3H-indol-3-one O-methyl oxime 
• 1022-46-4 2-phenyl-4H-3,1-benzoxazin-4-one 
• 64641-83-4 3-amino-2-phenylindole 
• 33738-86-2 N-(2-phenyl-1H-indol-3-yl)acetamide 
• 25344-22-3 2-phenyl-indol-3-one-(O-benzoyl oxime ) 
• 25344-21-2 2-phenyl-indol-3-on-(O-acetyl oxime ) 

Relevant articles and documents

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NaNO2/K2S2O8-mediated Selective Radical Nitration/Nitrosation of Indoles: Efficient Approach to 3-Nitro- and 3-Nitrosoindoles

JPZ acknowledges financial support from the National Natural Science Foundation of China (No. 21172163, 21472133), the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), and Key Laboratory of Organic Synthesis of Jiangsu Province (KJS1749). (Figure presented.).

Copper-Catalyzed Carbonyl Group Controlled Coupling of Isatin Oximes with Arylboronic Acids To Prepare N-Aryloxindole Nitrones

A variety of (E)-N-aryloxindole nitrones were prepared in good to excellent yields by using a copper-catalyzed coupling reaction of isatin oximes and arylboronic acids under mild conditions. Various arylboronic acids that contain sensitive functional groups were tolerated in the transformation, and detailed studies show that the carbonyl group of the isatin oximes serves as a ligand to control the formation of the (E)-oxindole nitrones. This method to prepare (E)-N-aryloxindole nitrones was easily performed on a gram scale and efficiently used to synthesize estrone-derived oxindole nitrone in high yield.